| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Common characters of known urination sensors are calcium channels and acid sensitivity. We gave acid stimuli to the mouse bladder epithelia under the condition that these channels were inhibited completely, and found calcium concentration increase of the cell inside by the stimulation pH < 5. It was suggested that this phenomenon was caused by the calcium entry from out of cells via calcium channel(s). The bladder epithelial cell response to acid stimuli was not observed in esophagus epithelial cells, that is, these findings indicated that the response mechanism to acid is specific to bladder epithelial cells.
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