Clarification the role of Aurora-A in renal cell carcinoma and development of novel treatment for it

• Project/Area Number: 23791755
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: TERAKAWA Tomoaki 神戸大学, 大学院・医学研究科, 医学研究員 (50533759)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 腎癌 / Aurora-A / 腎細胞癌 / AURORA-A

Research Abstract

The suppression of Aurora-A expression using shRNA is a useful therapeutic strategy against RCC through growth inhibition as well as enhanced chemosensitivity.

Research Products

• [Journal Article] Growth inhibition and enhancechemosensitivity induced by down-regulation of Aurora-A in human renal cell carcinoma Cakicells using short hairpin RNA (2011)
  • Author(s): Terakawa T, Miyake H, Kumano M, Fujisawa M
  • Journal Title: Oncology Letters Volume: 2 Pages: 713-717
  • Peer Reviewed
• [Journal Article] Growth inhibition and enhanced chemosensitivity induced by downregulation of Aurora-A in human renal cell carcinoma Caki-2 cells using short hairpin RNA (2011)
  • Author(s): TOMOAKI TERAKAWA
  • Journal Title: Oncology Letters Volume: 2 Issue: 4 Pages: 713-717
  • DOI: 10.3892/ol.2011.295
  • Peer Reviewed