Doxycycline: new therapy for renal ischemia reperfusion injury
Project/Area Number |
23791758
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Okayama University |
Principal Investigator |
ARAKI Motoo 岡山大学, 岡山大学病院, 講師 (90467746)
|
Research Collaborator |
HIROHATA Satoshi 岡山大学, 国際センター, 准教授 (90332791)
NINOMIYA Yoshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 腎虚血再潅流障害 / ドキシサイクリン / 細胞外マトリックス(MMP) / MMP 阻害薬 / 腎移植 / 腎虚血再灌流 / 急性腎不全 / MMP / MMP阻害薬 |
Research Abstract |
The protective effect of doxycycline was examined in murine renal ischemia reperfusion injury (IRI) model. The administration ofdoxycycline reduce renal IRI confirmed by reduced serum creatinine level and damage in histopathology. The mechanism was due to reduced neutrophil infiltration in renal tissue by matrix metalloproteinases (MMPs) inhibition by doxycycline.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Laparoscopic-assisted tension-free vaginal mesh: an innovative approach to placing synthetic mesh2012
Author(s)
Watanabe T, Inoue M, Ishii A, Yamato T, Yamamoto M, Sasaki K, Kobayashi Y, Araki M, Uehara S, Saika T, Kumon H
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Journal Title
transvaginally for surgical correction of pelvic organ prolapse
Volume: 66
Pages: 23-29
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[Presentation] 岡山大学泌尿器科における腎移植初期症例の検討2011
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荒木元朗,和田耕一郎,有吉勇一,上松克利,河内啓一郎,小武家誠,上原慎也,渡辺豊彦,雑賀隆史,那須保友,公文裕巳
Organizer
第47回日本移植学会総会
Place of Presentation
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Year and Date
2011-10-04
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河内啓一郎,上松克利,荒木元朗,石井和史,上原慎也,渡辺豊彦,雑賀隆史,那須保友,公文裕巳,二宮善文,廣畑 聡,三好 亨
Organizer
第99回日本泌尿器科学会総会
Place of Presentation
名古屋市
Year and Date
2011-04-21
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[Presentation] 岡山大学泌尿器科における腎移植初期症例の検討2011
Author(s)
荒木元朗,上松克利,河内啓一郎,小武家誠,上原慎也,渡辺豊彦,雑賀隆史,那須保友,公文裕巳,齋藤和英,高橋公太
Organizer
第99回日本泌尿器科学会総会
Place of Presentation
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Year and Date
2011-04-21
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