| Project/Area Number |
23791758
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
ARAKI Motoo 岡山大学, 岡山大学病院, 講師 (90467746)
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| Research Collaborator |
HIROHATA Satoshi 岡山大学, 国際センター, 准教授 (90332791)
NINOMIYA Yoshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腎虚血再潅流障害 / ドキシサイクリン / 細胞外マトリックス(MMP) / MMP 阻害薬 / 腎移植 / 腎虚血再灌流 / 急性腎不全 / MMP / MMP阻害薬 |
|---|
| Research Abstract |
The protective effect of doxycycline was examined in murine renal ischemia reperfusion injury (IRI) model. The administration ofdoxycycline reduce renal IRI confirmed by reduced serum creatinine level and damage in histopathology. The mechanism was due to reduced neutrophil infiltration in renal tissue by matrix metalloproteinases (MMPs) inhibition by doxycycline.
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