| Project/Area Number |
23791760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kagawa University |
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Principal Investigator |
HIRAMA Hiromi 香川大学, 医学部附属病院, 助教 (50552725)
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| Co-Investigator(Kenkyū-buntansha) |
KAKEHI Yoshiyuki 香川大学, 医学部, 教授 (20214273)
SUGIMOTO Mikio 香川大学, 医学部附属病院, 准教授 (10243768)
ZHANG Xia 香川大学, 医学部, 助教 (30524061)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 末梢血循環腫瘍細胞 / 腎癌 / Death Receptor 5 / 末梢循環癌細胞 / 腎癌患者 / 転移性癌患者 / 抹消血 / DR－５ / ＤＲ－５ |
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| Research Abstract |
This research was planned with the objective of detecting cancer cells at extremely low volumes circulating in the blood of renal cell carcinoma patients (circulating tumor cells (CTC) in peripheral blood), using fluorescence-labeled antibodies for DR-5, a surface marker of renal cancer cells.
In a preliminary experiment, it was possible to count renal cancer cells as CTC. However, in the peripheral blood of localized and metastatic renal cell carcinoma patients (respectively 15 and 4 patients), the positive detection rate for DR-5 was low, and CTC detection was difficult. Moreover, CTC measurement using the blood in the renal veins that first flowed from the kidneys was performed for 13 patients, but there was significant contamination given that this was subsequent to renal excision, and it was found to be unsuitable for CTC measurement.
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