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The role of bladder microcirculation and Kit positive interstitial cells in OAB

Research Project

Project/Area Number 23791769
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

KUBOTA Yasue  名古屋市立大学, 大学院・医学研究科, 講師 (00381830)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords過活動膀胱 / 間質細胞 / Kit / c-kit
Research Abstract

In the gastrointestinal tract, interstitial cells of Cajal (ICC) act as primary pacemaker cells, and play a fundamental role in the transmission of signals from enteric neurons to smooth muscle cells. In the urinary tract, including bladder, ICCs, which are referred to as interstitial cells (IC), ICC-like cells, or myofibroblasts, have also been identified by their morphological characteristics, but represent variability among tissues which may account for individual characteristics of organ. ICCs express the proto-oncogene c-kit, and signaling via the receptor kinase gene product, KIT, which is used as an identification marker of ICCs. Recent reports have suggested that KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Identifying the functions of ICCs and/or KIT may be a shortcut to clarify the pathophysiology of overactive bladder (OAB) and detrusor overactivity. Thus, in this study, we summarize the distribution and function of KIT-positive ICC and KIT in the bladder as well as the association between KIT-positive ICCs or KIT and OAB, and discuss the possible therapeutic target of KIT for OAB in the future. Finally, we demonstrated the usefulness of a possible objective biomarker for diagnosis and treatment efficacy, stem cell factor (SCF), which is a natural ligand for KIT.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (36 results)

All 2013 2012 2011 Other

All Journal Article (19 results) (of which Peer Reviewed: 17 results) Presentation (16 results) Book (1 results)

  • [Journal Article] Effect of Adiponectin on Kidney Crystal Formation in Metabolic Syndrome Model Mice via Inhibition of Inflammation and Apoptosis2013

    • Author(s)
      Fujii Y, Okada A, Yasui T, Niimi K,Hamamoto S, Hirose M, Kubota Y, Tozawa K, Hayashi Y, Kohri K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e61343-e61343

    • DOI

      10.1371/journal.pone.0061343

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of cell proliferation through a KIT-mediated mechanism in benign2012

    • Author(s)
      Imura M, Kojima Y, Kubota Y, Hamakawa T,Yasui T, Sasaki S, Hayashi Y, Kohri K.
    • Journal Title

      Prostate

      Volume: 72 Issue: 14 Pages: 1506-1513

    • DOI

      10.1002/pros.22500

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tamsulosin reduces nighttime urine production in benign prostatic Hyperplasia patients with nocturnal polyuria : A prospective open-label long-term study using frequency-volume chart2012

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Imura Makoto, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      Neurourology and Urodynamics

      Volume: 31 Issue: 1 Pages: 80-85

    • DOI

      10.1002/nau.21224

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis ofα_1-AR and its clinical application in male LUTS medical therapy2012

    • Author(s)
      Kojima Yoshiyuki, Kubota Yasue, Sasaki Shoichi, Kohri Kenjiro
    • Journal Title

      Current Bladder Dysfunction Reports

      Volume: 7 Issue: 4 Pages: 256-259

    • DOI

      10.1007/s11884-012-0149-4

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitocondrial permeability transition pore opening induces the initial process of renal calcium crystallization2012

    • Author(s)
      Niimi Kazuhiro, Yasui Takahiro, Hirose Masahito, Hamamoto Shuzo, Itoh Yasunori, Okada Atsushi, Kubota Yasue, Kojima Yoshiyuki, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 52 Issue: 7 Pages: 1207-1217

    • DOI

      10.1016/j.freeradbiomed.2012.01.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maternal anterior sacral meningocele presenting as acute urinary retention in pregnancy2012

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Kohri Kenjiro
    • Journal Title

      Int J Urol

      Volume: 19(3) Issue: 3 Pages: 279-80

    • DOI

      10.1111/j.1442-2042.2011.02940.x

    • NAID

      10030720339

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of osteopontin in early phase of renal crystal formation: immunohistochemical and microstructural comparisons with osteopontin knock-out mice2012

    • Author(s)
      Hirose M, Tozawa K, Okada A, Hamamoto S, Higashibata Y, Gao B, Hayashi Y, Shimizu H, Kubota Y, Yasui T, Kohri K
    • Journal Title

      Urol Res.

      Volume: 40 Issue: 2 Pages: 121-9

    • DOI

      10.1007/s00240-011-0400-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 過活動膀胱発症における膀胱上皮下KIT陽性間質細胞の意義。2012

    • Author(s)
      窪田 泰江
    • Journal Title

      排尿障害プラクティス

      Volume: 20 Pages: 24-31

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Maternal anterior sacral meningocele presenting as acute urinary retention in pregnancy.2012

    • Author(s)
      Kubota Yasue
    • Journal Title

      Int J Urol.

      Volume: 19(3) Pages: 279-280

    • NAID

      10030720339

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of KIT-positive interstitial cells of Cajal in the urinary bladder and possible therapeutic target for overactive bladder2011

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Shibata Yasuhiro, Imura Makoto, Kohri Kenjiro, Sasaki Shoichi
    • Journal Title

      Adv Urol

      Volume: Vol. 2011 Pages: 1-7

    • DOI

      10.1155/2011/816342

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between improvements in overactive bladder symptom score and health-related quality of life questionnaires in overactive bladder patients treated with an antimuscarinic drug2011

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Shibata Yasuhiro, Imura Makoto, Kohri Kenjiro, Sasaki Shoichi
    • Journal Title

      Neurourol Urodyn.

      Volume: 30(7) Issue: 7 Pages: 1309-1314

    • DOI

      10.1002/nau.21065

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation ofα_<1a> andα_<1d>-adrenoceptors in the prostate by administration of subtype selectiveα_1-adrenoceptor antagonist tamsulosin in patients with benign prostatic hyperplasia2011

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Kubota Yasue, Imura Makoto, Oda Nobuyuki, Kiniwa Mamoru, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      The Journal of Urology

      Volume: 186 Issue: 4 Pages: 1530-1536

    • DOI

      10.1016/j.juro.2011.05.048

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats2011

    • Author(s)
      Shibata Yasuhiro, Ugawa Shinya, Imura Makoto, Kubota Yasue, Ueda Takashi, Kojima Yoshiyuki, Ishida Yusuke, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Shimada Shoichi.
    • Journal Title

      Neuroreport

      Volume: 22(2) Issue: 2 Pages: 61-67

    • DOI

      10.1097/wnr.0b013e3283424c9c

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between expression ofα1-adrenoceptor subtype mRNA and severity of lower urinary tract symptoms or bladder outlet obstruction in benign prostatic hyperplasia patients2011

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Imura Makoto, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      BJU International

      Volume: 107 Issue: 3 Pages: 438-442

    • DOI

      10.1111/j.1464-410x.2010.09596.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of α(1)- adrenoceptor subtypes mediating contraction in human isolated ureters2011

    • Author(s)
      Sasaki Shoichi, Tomiyama Yoshitaka, Kobayashi Shinya, Kojima Yoshiyuki, Kubota Yasue, Kohri Kenjiro.
    • Journal Title

      Urology

      Volume: 77(3):762 Issue: 3 Pages: 762.e13-762.e17

    • DOI

      10.1016/j.urology.2010.09.034

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of bladder overactivity in KIT mutant rats2011

    • Author(s)
      Okada Shinsuke, Kojima Yoshiyuki, Kubota Yasue, Mizuno Kentaro, Sasaki Shoichi, Kohri Kenjiro
    • Journal Title

      BJU Int.

      Volume: 108(2 Pt 2) Issue: 2b

    • DOI

      10.1111/j.1464-410x.2010.09870.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 protects germ cells against spermatogenesis disturbance in experimental cryptorchidism model mice2011

    • Author(s)
      Kubota H, Sasaki S, Kubota Y, Umemoto Y, Yanai Y, Tozawa K, Hayashi Y, Kohri K
    • Journal Title

      Journal of Andrology

      Volume: 32 Issue: 1 Pages: 77-85

    • DOI

      10.2164/jandrol.109.008888

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between improvements in overactive bladder symptom score and health-related quality of life questionnaires in overactive bladder patients treated with an antimuscarinic drug.2011

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Shibata Yasuhiro, Imura Makoto, Kohri Kenjiro, Sasaki Shoichi.
    • Journal Title

      Neurourology & Urodynamics

      Volume: 30(7) Pages: 1309-1314

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of spermiogenesis by Numb and Numb-like in rat testes: analysis using an in vivo gene transfer technique

    • Author(s)
      Shoichiro Iwatsuki, Shoichi Sasaki, Kentaro Mizuno, Hiroki Kubota, Yasue Kubota, Yukihiro Umemoto, Takahiro Yasui, Yutaro Hayashi, Kenjiro Kohri
    • Related Report
      2012 Final Research Report
  • [Presentation] 教育講演(4) 最新情報:基礎 の Overview 「過活動膀胱におけるSCF-Kitシグナル伝達系の機能解析」2012

    • Author(s)
      窪田 泰江
    • Organizer
      第6回下部尿路機能先端セミナー
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Urinary stem cell factor as a novel diagnostic and therapeutic biomarker for overactive bladder2012

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Hamakawa Takashi, Imura Makoto, Shibata Yasuhiro, Sasaki Shoichi, Kohri Kenjiro
    • Organizer
      American Urological Association Annual Meeting 2012
    • Place of Presentation
      Atlanta(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Receptor binding ability of α1-AR antagonists is responsible for therapeutic efficiency with long-term use in benign prostatic hyperplasia2012

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Hamakawa Takashi, Shibata Yasuhiro, Imura Makoto, Kubota Yasue, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      American Urological Association Annual Meeting 2012
    • Place of Presentation
      Atlanta(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Gene expression profiling and functional network analysis of benign prostatic hyperplasia model rat2012

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Imura Makoto, Mizuno Kentaro, Okada Atsushi, Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      American Urological Association Annual Meeting 2012
    • Place of Presentation
      Atlanta(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of cell proliferation through a KIT-mediated mechanism.2012

    • Author(s)
      Imura Makoto, Kojima Yoshiyuki, Hamakawa Takashi, Okada Atsushi, Kubota Yasue, Umemoto Yukihiro, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      American Urological Association Annual Meeting 2012
    • Place of Presentation
      Atlanta(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] 過活動膀胱患者に対する層別解析を用いたイミダフェナシンの治療効果の検討2012

    • Author(s)
      窪田 泰江、小島 祥敬、佐々木 昌一、郡 健二郎、山田 泰之、窪田 裕樹、池内 隆人、多和田 俊保
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Final Research Report
  • [Presentation] 過活動膀胱患者に対する層別解析を用いたイミダフェナシンの治療効果の検討。2012

    • Author(s)
      窪田 泰江
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Urinary stem cell factor as a novel diagnostic and therapeutic biomarker for overactive bladder.2012

    • Author(s)
      Kubota Yasue
    • Organizer
      American Urological Association Annual Meeting 2012
    • Place of Presentation
      Atlanta(USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 教育講演④最新情報:基礎のOverview。2012

    • Author(s)
      窪田 泰江
    • Organizer
      第6回下部尿路機能先端教育セミナー
    • Place of Presentation
      六本木アカデミーヒルズ(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of cell proliferation through a KIT-mediated mechanism in benign prostatic hyperplasia.2012

    • Author(s)
      Imura Makoto
    • Organizer
      Nagoya Shinshu Forum
    • Place of Presentation
      名古屋マリオットアソシアホテル(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Urinary stem cell factor as a novel diagnostic and therapeutic biomarker for overactive bladder.2012

    • Author(s)
      Shibata Yasuhiro
    • Organizer
      第32回国際泌尿器科学会(SIU)
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 尿中Stem Cell Factor (SCF)値の測定はOABの診断と治療効果判定に有用である2011

    • Author(s)
      窪田 泰江、小島 祥敬、井村 誠、柴田 泰宏、佐々木 昌一、郡 健二郎
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井市
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of KIT-positive interstitial cells in the urinary bladder.2011

    • Author(s)
      Kubota Yasue
    • Organizer
      Roles, mechanisms and origin of various cell types in visceral smooth muscles
    • Place of Presentation
      Gamagoori
    • Related Report
      2012 Final Research Report
  • [Presentation] SCF/KITシグナル伝達系を標的とした過活動膀胱に対する新しい治療戦略2011

    • Author(s)
      窪田 泰江、小島 祥敬、佐々木 昌一、郡 健二郎
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of KIT-positive interstitial cells in the urinary bladder.2011

    • Author(s)
      Kubota Yasue
    • Organizer
      Roles, mechanisms and origin of various cell types in visceral smooth muscles
    • Place of Presentation
      銀波荘(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 尿中Stem Cell Factor (SCF)値の測定はOABの診断と治療効果判定に有用である。2011

    • Author(s)
      窪田泰江
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      ホテルフジタ福井/福井フェニックスプラザ(福井県)
    • Related Report
      2011 Research-status Report
  • [Book] 臨床医学の展望2012 泌尿器科学2012

    • Author(s)
      窪田 泰江
    • Publisher
      日本医事新報社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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