| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
We investigated the predictive factor associated with the effect of the peptide vaccine treatment using clinical specimen. The expression of MPHOSPH1 and DEPDC1 antigen were recognized in all cases, but there was no correlation between expression intensity and grade and stage of the tumor. Cases 80% or more showed CTL induction after vaccination, and the CTL induction was maintained during follow-up period. The patient in recognition of the response of the vaccine administration site showed a decrease of the recurrence rate as compared with an absent case. Performance Status, CTL induction and injection site reaction were identified as an associated factor of the peptide vaccine treatment.
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