The relationship between microenvironment and growth of the cellsregulated by EBAG9 in bladder cancer
Project/Area Number |
23791783
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Saitama Medical University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 腫瘍学 / EBAG9 / がん / 微小環境変化 / 腫瘍免疫 / Cancer / microenvironment / tumor immunity / 前立腺がん |
Research Abstract |
Mouse bladder cancer cells were subcutaneously implanted into Ebag9 knockout mice and control mice. We found that tumor volumes generated in Ebag9 knockoutmice were smaller than that of control mice. Furthermore, numbers of T cell infiltration increased in implanted tumors of Ebag9 knockout mice. We analyzed the expression of immune-related genes in the T cells derived from tumors using qPCR. Notably, tumor metastasis in lung was suppressed in Ebag9 knockout mice. We assume that EBAG9 may regulate tumor growth and migration by regulating immune response of host cells.
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Report
(3 results)
Research Products
(7 results)