Establishment of the treatment strategy for the superficial and invasive bladder cancer cell using the bafilomycin

• Project/Area Number: 23791784
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: YOSHIMINE Shunsuke 慶應義塾大学, 医学部, 助教 (70445245)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 癌 / 癌治療 / 膀胱癌 / 化学療法 / バフィロマイシン / 尿路上皮癌 / アポトーシス / 予後因子 / 動物モデル / 抗癌剤

Research Abstract

The bafilomycin induced antitumor effect of bladder cancer cell lines through the inhibition of the Bcl-xL protein function. The Bcl-xL protein was presented at high frequency in the specimen of the upper urinary tract urothelial carcinoma and the high ex

Research Products

• [Journal Article] Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelialcarcinoma. (2013)
  • Author(s): Shunsuke Yoshimine, Eiji Kikuchi, Takeo Kosaka, Shuji Mikami, Akira Miyajima, Yasunori Okada, Mototsugu Oya.
  • Journal Title: British Journal of Cancer (2013) Volume: 108 Issue: 11 Pages: 1-9
  • DOI: 10.1038/bjc.2013.216
  • Peer Reviewed
• [Presentation] Prognostic significance of Bcl-xL protein expression on survival in patents with upper tract urothelial carcinoma treated with radical nephroureterectomy.Annual Meeting of the American Urological Association. (2013)
  • Author(s): Shunsuke Yoshimine, Eiji Kikuchi, Takeo Kosaka, Shuji Mikami, Akira Miyajima, Yasunori Okada, Mototsugu Oya
  • Organizer: Annual Meeting of the American Urological Association
  • Place of Presentation: SAN DIEGO CA USA, San Diego Convention Center
  • Year and Date: 2013-05-05
• [Presentation] 上部尿路上皮癌におけるBcl-xLの発現と予後との関連の検討 (2012)
  • Author(s): 吉峰 俊輔、菊地 栄次、小坂 威雄、宮嶋哲、大家 基嗣
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-22
• [Presentation] 上部尿路上皮癌におけるBcl-xLの発現と予後との関連の検討 (2012)
  • Author(s): 吉峰 俊輔
  • Organizer: 第100回 日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 上部尿路上皮癌におけるBcl-xLの発現と予後との関連の検討 (2012)
  • Author(s): 吉峰 俊輔、菊地 栄次、小坂 威雄、宮嶋 哲、大家 基嗣
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県）