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Liposomal IL-21/IL-15 Gene Therapy in an Orthotopic Bladder Cancer Model and Prevention of Tumor Invasion and Metastasis

Research Project

Project/Area Number 23791788
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKeio University

Principal Investigator

MATSUSHIMA Masashi  慶應義塾大学, 医学部, 助教 (00464850)

Research Collaborator MATSUMOTO Kazuhiro  慶應義塾大学, 医学部, 助教 (80366153)
KIKUCHI Eiji  慶應義塾大学, 医学部, 講師 (10286552)
MIYAJIMA Akira  慶應義塾大学, 医学部, 講師 (90245572)
OYA Mototsugu  慶應義塾大学, 医学部, 教授 (00213885)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords膀胱癌 / インターロイキン21 / 遺伝子導入 / 膀胱内注入 / IL-21 / IL-15 / マウス膀胱癌同所性モデル
Research Abstract

We transfected IL-21 plasmid to MBT2 cells, and the supernatant IL-21 level was measured by ELISA after the transfection of IL-21 gene. The peak IL-21level was observed 24 hr after the transfection of IL-21 plasmids. Next, we established the orthotopic bl

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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