Construction of the tailor-made medicine for prostate cancer with bone metastasis using bone turnover metabolites
Project/Area Number |
23791792
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Toho University |
Principal Investigator |
KAMIYA Naoto 東邦大学, 医学部, 講師 (40436431)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 前立腺 / 骨転移 / MMP / 骨代謝マーカー / 前立腺癌 |
Research Abstract |
Serum MMP-2 level correlated with tumor grade and the extent of bone metastases in prostate cancer (PCa) with bone metastases. We determined that the additive effect of zoledronic acid (ZA) on serum PSA and bone turnover markers changes for hormone-sensitive PCa patients with bone metastasis treated by combined androgen blockade (CAB). The addition of ZA to CAB therapy showed PSA and ALP response compared with CAB therapy only, suggesting a potential antitumor effect of ZA in the management of metastatic PCa patients. Furthermore, to clarify clinical predictors for a PSA decrease >50% in response to alternative non-steroidal antiandrogen therapy (AA) and to develop a nomogram to predict the PSA decrease >50% in response to AA in patients with advanced PCa that relapsed after initial CAB. The receiver operating characteristic curve showed that the accuracy of the predicted probability was 72.5% for the model.
|
Report
(4 results)
Research Products
(34 results)
-
[Journal Article] Development of nomogram to non-steroidal antiandrogen sequential alternation in prostate cancer for predictive model.2014
Author(s)
Kamiya N, Suzuki H, Nishimura K, Fujii M, Okegawa T, Matsuda T, Morita T, Takihana Y, Ozono S, Namiki M, Matsubara A, Ichikawa T, Miki T.
-
Journal Title
Jpn J Clin Oncol.
Volume: 44
Issue: 3
Pages: 263-269
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy for Japanese patients with castration-resistant prostate cancer: a retrospective multi-institutional collaborative study.2013
Author(s)
Kamiya N, Suzuki H, Ueda T, Sato N, Nakatsu H, Mikami K, Sato N, Nomura K, Akakura K, Okano T, Ooki T, Naya Y, Ota S, Masai M, Ichikawa T.
-
Journal Title
Int J Clin Oncol.
Volume: 19
Issue: 1
Pages: 157-164
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性2011
Author(s)
遠藤匠, 神谷直人, 岡了, 杉浦恵子, 高野慎, 矢野仁, 直井牧人, 川村幸治, 今本敬, 高波 眞佐治, 市川智彦, 鈴木啓悦
Organizer
第49回日本癌治療学会学術集会
Place of Presentation
名古屋国際会議場(愛知県)
Related Report
-
[Presentation] Clinical Outcomes by Relative Docetaxel Dose and Dose Intensity as Chemotherapy for Japanese Patients with Castration-Resistant Prostate Cancer: A Retrospective Multi-Institutional Collaborative Study.
Author(s)
Kamiya N, Suzuki H, Ueda T, Sato N, Nakatsu H, Mikami K, Sato N, Nomura K, Akakura K, Okano T, Ooki T, Naya Y, Ota S, Masai M, Ichikawa T.
Organizer
AUA ANNUAL MEETING 2013
Place of Presentation
サンディエゴ(米国)
Related Report
-
-
-
-
-
-
-
-
-
-