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Construction of the tailor-made medicine for prostate cancer with bone metastasis using bone turnover metabolites

Research Project

Project/Area Number 23791792
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionToho University

Principal Investigator

KAMIYA Naoto  東邦大学, 医学部, 講師 (40436431)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords前立腺 / 骨転移 / MMP / 骨代謝マーカー / 前立腺癌
Research Abstract

Serum MMP-2 level correlated with tumor grade and the extent of bone metastases in prostate cancer (PCa) with bone metastases. We determined that the additive effect of zoledronic acid (ZA) on serum PSA and bone turnover markers changes for hormone-sensitive PCa patients with bone metastasis treated by combined androgen blockade (CAB). The addition of ZA to CAB therapy showed PSA and ALP response compared with CAB therapy only, suggesting a potential antitumor effect of ZA in the management of metastatic PCa patients.
Furthermore, to clarify clinical predictors for a PSA decrease >50% in response to alternative non-steroidal antiandrogen therapy (AA) and to develop a nomogram to predict the PSA decrease >50% in response to AA in patients with advanced PCa that relapsed after initial CAB. The receiver operating characteristic curve showed that the accuracy of the predicted probability was 72.5% for the model.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (15 results) Book (8 results)

  • [Journal Article] Development of nomogram to non-steroidal antiandrogen sequential alternation in prostate cancer for predictive model.2014

    • Author(s)
      Kamiya N, Suzuki H, Nishimura K, Fujii M, Okegawa T, Matsuda T, Morita T, Takihana Y, Ozono S, Namiki M, Matsubara A, Ichikawa T, Miki T.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 44 Issue: 3 Pages: 263-269

    • DOI

      10.1093/jjco/hyt230

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy for Japanese patients with castration-resistant prostate cancer : a retrospective multi-institutional collaborative study2013

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Clin Oncol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy for Japanese patients with castration-resistant prostate cancer: A retrospective multi-institutional collaborative study2013

    • Author(s)
      Kamiya N, Suzuki H, Ueda T, Sato N, Nakatsu H, Mikami K, Sato N, Nomura K, Akakura K, Okano T, Ooki T, Naya Y, Ota S, Masai M, Ichikawa T.
    • Journal Title

      Int J Clin Oncol.

      Volume: 19 Issue: 1 Pages: 157

    • DOI

      10.1007/s10147-012-0510-9

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical usefulness of bone markers in prostate cancer with bone metastasis2012

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Urol

      Volume: 19 Pages: 968-979

    • NAID

      10031126769

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Additive effect of zoledronic acid on serum prostate-specific antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade2012

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Urol

      Volume: 19 Pages: 169-173

    • NAID

      10031184801

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌骨転移症例に対する血清破骨細胞活性マーカーの臨床的意義2012

    • Author(s)
      神谷直人,鈴木啓悦, 他
    • Journal Title

      日本腎泌尿器疾患予防医学研究会誌

      Volume: 20 Pages: 75-77

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical usefulness of bone markers in prostate cancer with bone metastasis.2012

    • Author(s)
      Kamiya N, Suzuki H, Endo T, Yano M, Naoi M, Nishimi D, Kawamura K, Imamoto T, Ichikawa T.
    • Journal Title

      Int J Urol.

      Volume: 19 Pages: 968-979

    • NAID

      10031126769

    • Related Report
      2012 Research-status Report
  • [Journal Article] Additive effect of zoledronic acid on serum prostate-specific antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade.2012

    • Author(s)
      Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Nishimi D, Kawamura K, Imamoto T, Ichikawa T.
    • Journal Title

      International Journal of Urology

      Volume: 19 Pages: 169-173

    • NAID

      10031184801

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of serum osteoprotegerin and receptor activator of nuclear factor kappa B ligand in Japanese prostate cancer patients with bone metastasis2011

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Pages: 366-372

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌骨転移症例における血清骨代謝マーカーの臨床的意義2011

    • Author(s)
      神谷直人,鈴木啓悦, 他
    • Journal Title

      日本腎泌尿器疾患予防医学研究会誌

      Volume: 19 Pages: 93-94

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 08 Significance of serum osteoprotegerin and receptor activator of nuclear factor kappa B ligand in Japanese prostate cancer patients with bone metastasis.2011

    • Author(s)
      Kamiya N, Suzuki H, Endo T, Takano M, Yano M, Naoi M, Kawamura K, Imamoto T, Takanami M, Ichikawa T
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 16 Pages: 366-372

    • Related Report
      2011 Research-status Report
  • [Presentation] 再燃前立腺癌における抗アンドロゲン剤交替療法の有用性を予測する検討NASA-PC-PM2013

    • Author(s)
      神谷直人
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] CLINICAL OUTCOMES BY RELATIVE DOCETAXEL DOSE AND DOSE INTENSITY AS CHEMOTHERAPY WITH CASTRATIONRESISTANT PROSTATE CANCER : A RETROSPECTIVE MULTI-INSTITUTIONAL COLLABORATIVE STUDY2013

    • Author(s)
      Naoto Kamiya
    • Organizer
      America Urological Association Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2013-05-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Additive ellect of zoledronic acid on serum prostate-specilic antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade2012

    • Author(s)
      Naoto Kamiya
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢
    • Year and Date
      2012-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の臨床学的意義2012

    • Author(s)
      神谷直人
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] CLINICAL OUTCOMES OF SERUM BONE TURNOVER MARKERS IN PROSTATE CANCER WITH BONE METASTASIS2012

    • Author(s)
      Naoto Kamiya
    • Organizer
      America Urological Association Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2012-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性2012

    • Author(s)
      神谷直人
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性2011

    • Author(s)
      神谷直人
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 去勢抵抗性前立腺癌に対するドセタキセル療法の臨床学的検討~多施設共同研究~2011

    • Author(s)
      神谷直人
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 前立腺癌骨転移症例に対する血清破骨細胞活性マーカーの臨床学的意義2011

    • Author(s)
      神谷直人
    • Organizer
      第20回日本腎泌尿器疾患予防医学研究会
    • Place of Presentation
      前橋
    • Year and Date
      2011-07-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸療法の意義2011

    • Author(s)
      神谷直人
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 前立腺癌骨転移症例に対する血清破骨細胞活性マーカーの臨床学的意義2011

    • Author(s)
      神谷直人、鈴木啓悦、岡了、杉浦恵子、遠藤匠、高野慎、矢野仁、直井牧人、西見大輔、川村幸治、今本敬、高波 眞佐治、市川智彦
    • Organizer
      第20回日本腎泌尿器疾患予防医学研究会
    • Place of Presentation
      前橋テルサ(群馬県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性2011

    • Author(s)
      遠藤匠, 神谷直人, 岡了, 杉浦恵子, 高野慎, 矢野仁, 直井牧人, 川村幸治, 今本敬, 高波 眞佐治, 市川智彦, 鈴木啓悦
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Clinical Outcomes by Relative Docetaxel Dose and Dose Intensity as Chemotherapy for Japanese Patients with Castration-Resistant Prostate Cancer: A Retrospective Multi-Institutional Collaborative Study.

    • Author(s)
      Kamiya N, Suzuki H, Ueda T, Sato N, Nakatsu H, Mikami K, Sato N, Nomura K, Akakura K, Okano T, Ooki T, Naya Y, Ota S, Masai M, Ichikawa T.
    • Organizer
      AUA ANNUAL MEETING 2013
    • Place of Presentation
      サンディエゴ(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性

    • Author(s)
      神谷直人
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の臨床学的意義

    • Author(s)
      神谷直人
    • Organizer
      日本癌治療学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Book] 抗がん薬の臨床薬理2013

    • Author(s)
      神谷直人, 他
    • Total Pages
      334
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report
  • [Book] 前立腺癌と男性骨粗鬆症 最新 骨管理マニュアル2013

    • Author(s)
      神谷直人, 鈴木啓悦
    • Total Pages
      268
    • Publisher
      医学図書出版
    • Related Report
      2013 Annual Research Report
  • [Book] 抗がん薬の臨床薬理2013

    • Author(s)
      神谷直人, 鈴木啓悦
    • Total Pages
      731
    • Publisher
      南山堂
    • Related Report
      2013 Annual Research Report
  • [Book] 前立腺癌と男性骨粗鬆症最新骨管理マニュアル2013

    • Author(s)
      細井孝之、松島常
    • Total Pages
      268
    • Publisher
      医学図書出版株式会社
    • Related Report
      2012 Research-status Report
  • [Book] 前立腺癌と男性骨粗鬆症最新骨管理マニュアル2012

    • Author(s)
      神谷直人, 他
    • Total Pages
      155
    • Publisher
      医学図書出版
    • Related Report
      2013 Final Research Report
  • [Book] 成功・失敗の傾向,各疾患の特徴からつかむ臨床試験計画とデザインの設定2012

    • Author(s)
      神谷直人, 他
    • Total Pages
      242
    • Publisher
      技術情報協会
    • Related Report
      2013 Final Research Report
  • [Book] 前立腺癌のすべて第3版2011

    • Author(s)
      神谷直人, 他
    • Total Pages
      346
    • Publisher
      メディカルビュー社
    • Related Report
      2013 Final Research Report
  • [Book] 第3版 前立腺癌のすべて2011

    • Author(s)
      鈴木啓悦,神谷直人,矢野仁,ほか
    • Total Pages
      18
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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