Roles of branched-type disialyl- antigen in malignant conversion in renal cell cancer
| Project/Area Number |
23791796
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | The Noguchi Institute |
|---|
Principal Investigator |
TSUCHIDA Akiko 公益財団法人野口研究所, 研究部, 研究員 (70378024)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 腎癌 / 糖脂質 / 糖転移酵素 / ジシアリル糖鎖 / 腫瘍マーカー / Disialyl糖鎖 / 転移 |
|---|
| Research Abstract |
Flow cytometric analysis of RCCs revealed that GalNAc-DSLc4 is presented on the cell surface in 70% of RCC lines. To investigate the roles of GalNAc-DSLc4 antigen in RCC, we prepared GalNAc-DSLc4-overexpressing transfectant cells using VMRC-RCW cells. They showed increased proliferation and invasion activities, and specific adhesion onto laminin-coating plates. These results suggest that GalNAc-DSLc4 is, at least partly, involved in the malignant properties of RCCs. And recently, we found that PI3K inhibitor (LY294002) suppresses malignant phenotype in GalNAc-DSLc4-overexpressing transfectant.
|
Report
(3 results)
Research Products
(5 results)
