| Project/Area Number |
23791796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | The Noguchi Institute |
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Principal Investigator |
TSUCHIDA Akiko 公益財団法人野口研究所, 研究部, 研究員 (70378024)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腎癌 / 糖脂質 / 糖転移酵素 / ジシアリル糖鎖 / 腫瘍マーカー / Disialyl糖鎖 / 転移 |
|---|
| Research Abstract |
Flow cytometric analysis of RCCs revealed that GalNAc-DSLc4 is presented on the cell surface in 70% of RCC lines. To investigate the roles of GalNAc-DSLc4 antigen in RCC, we prepared GalNAc-DSLc4-overexpressing transfectant cells using VMRC-RCW cells. They showed increased proliferation and invasion activities, and specific adhesion onto laminin-coating plates. These results suggest that GalNAc-DSLc4 is, at least partly, involved in the malignant properties of RCCs. And recently, we found that PI3K inhibitor (LY294002) suppresses malignant phenotype in GalNAc-DSLc4-overexpressing transfectant.
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