Identification of miRNA and its target gene by proteome analysis in hormone refractory prostate cancer

• Project/Area Number: 23791798
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: 公益財団法人神奈川科学技術アカデミー (2012); Kanagawa Academy of Science and Technology (2011)
• Principal Investigator: ISHIGURO Hitoshi 公益財団法人神奈川科学技術アカデミー, 重点研究室光触媒グループ, 研究員 (00381666)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 腫瘍学 / miRNA / 再燃 / 前立腺癌

Research Abstract

micro RNAs (miRNAs) regulate many genes and therefore their expression abnormality cause various diseases including cancer. Previously, we identified some miRNAs that might be related with prostate cancer progression. In this study, we found that miR-30d expression in cancer cells and tissues is higher than in normal prostate cells and tissues. Further, miR-30d expression was associated with recurrence free survival ratio. Therefore miR-30d might be a prognosis factor for prostate cancer recurrence. We identified that SOCS1 was one of the targets for miR-30d. SOCS1 regulation by miR-30 was related with prostate cancer progression.

Research Products

• [Journal Article] Identification of miR-30d as a novel prognostic maker of prostate cancer. (2012)
  • Author(s): Kobayashi N, Uemura H, Nagahama K, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H
  • Journal Title: Oncotarget Volume: 3 Pages: 1455-1471
  • URL: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=696
  • Peer Reviewed
• [Journal Article] Identification of miR-30d as a novel prognostic maker of prostate cancer (2012)
  • Author(s): Kobayashi N
  • Journal Title: Oncotarget Volume: 3 Pages: 1455-1471
  • Peer Reviewed
• [Journal Article] The co-expression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence (2011)
  • Author(s): Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano J, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y and Uemura H
  • Journal Title: Cancer Science Volume: 102 Issue: 8 Pages: 1576-1581
  • DOI: 10.1111/j.1349-7006.2011.01972.x
  • NAID: 10030242512
  • Peer Reviewed
• [Presentation] Identification of miR-30d as a novel prognostic maker of prostate cancer (2013)
  • Author(s): Kobayashi N, Uemura H, Nagahama N, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H.
  • Organizer: 19th International Charles Heidelberger Symposium on Cancer Research
  • Place of Presentation: Kagoshima
• [Presentation] Overexpression of miR-30d modulates cancer progression through the downregulation of SOCS1 (2012)
  • Author(s): Kobayashi N, Uemura H, Nagahama N, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H.
  • Organizer: 15th International Congress on Hormonal Steroids and Hormones & Cancer
  • Place of Presentation: Kanazawa
• [Presentation] miR-30d promotes prostate cancer progression and associated with early biochemical recurrence (2012)
  • Author(s): 古林直人、上村博司、長濱清隆、奥寺康司、古屋充子、井野洋子、伊藤悠亮、平野久、稲山嘉明、青木一郎、長嶋洋治、窪田吉信、石黒斉
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌