Functional analysis of estrogen receptor beta-targeting candidate gene Basonuclin1.
| Project/Area Number |
23791803
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 生殖 / 不妊 / 卵成熟 / SUMO化 / Bnc1 / エストロゲン受容体beta |
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| Research Abstract |
Basonuclin1 (Bnc1) gene is specifically expressed in germ cells and keratinocyte. We have identified the possibility of that Bnc1 gene expression is regulated by estrogen receptor beta. Our findings include: The localization of Bnc1 is slightly different from that of Bnc1 during early oocyte maturation; Bnc1 has another isoform and it localizes in cytoplasm; This isoform is specifically sumoylated with SUMO2/3.
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Report
(4 results)
Research Products
(8 results)
