Molecular analysis of growth of endometoriotic tissue affected by local estrogen production

• Project/Area Number: 23791805
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: TOKUNAGA HIDEKI 東北大学, 大学病院, 助教 (30595559)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: SF-1 / 子宮内膜症 / エストロゲン / アロマターゼ / StAR / 正常子宮内膜

Research Abstract

Steridgenic factor-1 plays a key-role for local estrogen synthesis in endometriotic stromal cells. Induction of SF-1 gene in endometrial stromal cells increased expression of StAR mRNA and protein but not other targets of SF-1. These results suggests gene group that regulates estrogen synthesis needs not only SF-1 gene expression but other factors.

Research Products

• [Journal Article] Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. (2014)
  • Author(s): Takano T, Otsuki T, Tokunaga H, Toyoshima M, Utsunomiya H, Nagase S, Niikura H, Ito K, Yaegashi N, Yamada H, Tase T, Kagabu M, Shoji T, Sugiyama T, Sato N, Fujimoto T, Terada Y, Kigawa J , et al.
  • Journal Title: International Journal of Clinical Oncology Volume: -
  • Peer Reviewed
• [Journal Article] Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterine cervical cancer. (2014)
  • Author(s): Tanaka S, Nagase S, Kaiho-Sakuma M, Nagai T, Kurosawa H, Toyoshima M, Tokunaga H, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N.
  • Journal Title: Int J Clin Oncol Volume: 19 Issue: 1 Pages: 133-138
  • DOI: 10.1007/s10147-013-0534-9
  • Peer Reviewed
• [Journal Article] Feasibility study of gemcitabine plus docetaxel in advanced or recurrent uterine leiomyosarcoma and undifferentiated endometrial sarcoma in Japan. (2013)
  • Author(s): Takano T, Niikura H, Ito K, Nagase S, Utsunomiya H, Otsuki T, Toyoshima M, Tokunaga H, Kaiho-Sakuma M, Shiga N, Nagai T, Tanaka S, Otsuki A, Kurosawa H, Shigeta S, Tsuji K, Yamaguchi T, Yaegashi N
  • Journal Title: International Journal of Clinical Oncology Volume: -
  • Peer Reviewed
• [Journal Article] Tracer injection sites and combinations for sentinel lymph node detection in patients with endometrial cancer. (2013)
  • Author(s): Niikura H, Kaiho-Sakuma M, Tokunaga H, Toyoshima M, Utsunomiya H, Nagase S, Takano T, Watanabe M, Ito K, Yaegashi N
  • Journal Title: Gynecol Oncol. Volume: 131 Issue: 2 Pages: 299-303
  • DOI: 10.1016/j.ygyno.2013.08.018
  • Peer Reviewed
• [Journal Article] 【進行婦人科がんの集学的治療】 子宮体がん 子宮がん肉腫・子宮肉腫の治療戦略(解説/特集) (2013)
  • Author(s): 高野忠夫、徳永英樹、八重樫伸生
  • Journal Title: 臨床婦人科産科 Volume: 67巻11号 Pages: 1139-1144
• [Journal Article] Small Cell Carcinoma of the Uterine Cervix: Clinical Outcome of Concurrent Chemoradiotherapy with a Multidrug Regimen. (2013)
  • Author(s): Tokunaga H, Nagase S, Yoshinaga K, Tanaka S, Nagai T, Kurosawa H, Kaiho-Sakuma M, Toyoshima M, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N
  • Journal Title: Tohoku J Exp Med. Volume: 229 Pages: 75-81
  • NAID: 10031143090
  • Peer Reviewed
• [Journal Article] Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterine cervical cancer. (2013)
  • Author(s): Tanaka S, Nagase S, Kaiho-Sakuma M, Nagai T, Kurosawa H, Toyoshima M, Tokunaga H, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N.
  • Journal Title: Int J Clin Oncol. Volume: 掲載確定
  • Peer Reviewed
• [Journal Article] Role of estrogen receptor-βin endometriosis (2012)
  • Author(s): Bulun SE, Monsavais D, Pavone ME, Dyson M, Xue Q, Attar E, Tokunaga H, Su EJ
  • Journal Title: Semin Reprod Med. Volume: 30(1) Issue: 01 Pages: 39-45
  • DOI: 10.1055/s-0031-1299596
  • Peer Reviewed
• [Presentation] 子宮内膜癌における Steroid sulfatase 阻害剤の有効性に関する検討 (2013)
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、辻圭太、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第65回日本産科婦人科学会
  • Place of Presentation: 札幌
  • Year and Date: 2013-05-11
• [Presentation] 子宮内膜癌における Steroid Sulfatase 阻害剤の有用性に関する検討 (2012)
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、山下泰恒、辻圭太、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第25回日本内分泌学会東北地方会
  • Place of Presentation: 秋田
  • Year and Date: 2012-11-17
• [Presentation] Surgical outcomes of fertility-sparing radical abdominal trachelectomy for early-stage uterine cervical cancer
  • Author(s): 徳永英樹、大槻健郎、横山良仁、水沼英樹、西山浩、藤森敬也、太田剛、倉智智久、庄子忠弘、杉山徹、佐藤直樹、寺田幸弘、田勢亨、新倉仁、八重樫伸生
  • Organizer: ASGO
  • Place of Presentation: 京都
• [Presentation] 子宮内膜癌におけるSteroid sulfatase 阻害剤の有効性に関する検討
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第61回北日本産科婦人科学会
  • Place of Presentation: 旭川
• [Presentation] 子宮内膜癌におけるSteroid sulfatase 阻害剤の有用性に関する検討
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、辻圭太、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第65回日本産婦人科学会
  • Place of Presentation: 札幌
• [Presentation] 子宮頸部小細胞癌に多剤用同時化学放射線法を施行した自験例の検討
  • Author(s): 田中創太、大槻愛、永井智之、海法道子、徳永英樹、大槻健郎、吉永浩介、永瀬智、高野忠夫、新倉仁、伊藤潔、八重樫伸生
  • Organizer: 第65回日本産婦人科学会
  • Place of Presentation: 札幌
• [Presentation] 子宮内膜癌におけるSteroid Sulfatase阻害剤の有用性に関する検討
  • Author(s): 西本光男、宇都宮裕貴、志賀尚美、山下泰恒、辻圭太、海法道子、鈴木史彦、徳永英樹、伊藤潔、八重樫伸生
  • Organizer: 第25回日本内分泌学会東北地方会
  • Place of Presentation: 秋田