The relationship between ovarian function and expression of Mvk

• Project/Area Number: 23791807
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Gunma University
• Principal Investigator: IKEDA Sadatomo 群馬大学, 医学部, 助教 (60568252)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 卵巣 / ゴナドトロピン / 脂質代謝 / 機能調節

Research Abstract

It has been reported that Mvk binds to LHR mRNA and stimulates the digestion of this mRNA as post-translational regulation. The production of Mvk was inhibited by E2 and stimulated by IL-6 and TNFα in granulosa cell culture.In the uterus, Mvk expression decreased after hCG treatment of immature rats. These results suggest that functional LHR are present in the uterus and are downregulated by hCG induced hCG.

Research Products

• [Journal Article] Glucose-Regulated Protein, 78-Kilodalton as a Modulator of Luteinizing Hormone Receptor Expression in Luteinizing Granulosa Cells in Rats (2013)
  • Author(s): Kogure K, Nakamura K, Ikeda S, Kitahara Y, Nishimura T, Iwamune M, Minegishi T
  • Journal Title: Biol Reprod Volume: 88 Pages: 8-8
  • Peer Reviewed
• [Journal Article] Glucose-Regulated Protein, 78-Kilodalton as a Modulator of Luteinizing Hormone Receptor Expression in Luteinizing Granulosa Cells in Rats. (2013)
  • Author(s): Kogure K, Nakamura K, Ikeda S, Kitahara Y, Nishimura T, Iwamune M, Minegishi T.
  • Journal Title: Biol Reprod Volume: 88(1) Issue: 1 Pages: 132-139
  • DOI: 10.1095/biolreprod.112.101873
  • Peer Reviewed
• [Journal Article] GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial cancer (2012)
  • Author(s): Luvsandagva B, Nakamura K, Kitahara Y, Aoki H, Murata T, Ikeda S, Minegishi T
  • Journal Title: Gynecol Oncol Volume: 126 Pages: 132-139
  • Peer Reviewed
• [Journal Article] GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial cancer. (2012)
  • Author(s): Luvsandagva Baigalimaa
  • Journal Title: Gynecologic Oncology Volume: 126 Issue: 1 Pages: 132-139
  • DOI: 10.1016/j.ygyno.2012.04.025
  • Peer Reviewed