Significance of endoplasmic reticulum stress in endometriosis as a chronic inflammatory disease
| Project/Area Number |
23791813
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HASEGAWA Akiko 東京大学, 学部付属病院女性診療科, 臨床登録医 (50598159)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 子宮内膜症 / 慢性炎症 |
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| Research Abstract |
In patients with endometriosis, the endoplasmic reticulum stress in endometrial tissue is different from the normal women. Difference of endoplasmic reticulum stress is also detected between the endometriosis tissue and the endometrial tissue. In endometriotic and endometrial stromal cells, endoplasmic reticulum stress induced chronic inflammatory cytokine, which induced further endoplasmic reticulum stress, resulted in endometriosis progression. In endometriotic stromal cells, chronic inflammation and Th2 immunological effect synergistically induced estron production, which also suggested to exacerbate the disease.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells2013
Author(s)
Urata Y, Osuga Y, Akiyama I, Nagai M, Izumi G, Takamura M, Hasegawa A, Harada M, Hirata T, Hirota Y, Yoshino O, Koga K, Kozuma S
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Journal Title
J Clin Endocrinol Metab
Volume: 98(4)
Issue: 4
Pages: 1583-90
DOI
Related Report
Peer Reviewed
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[Journal Article] Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-α (Gro-α) from endometrioma stromal cells2012
Author(s)
Takamura M, Osuga Y, Izumi G, Yoshino O, Koga K, Saito A, Hirata T, Hirota Y, Harada M, Hasegawa A, Taketani Y
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Journal Title
Fertil Steril
Volume: 98
Issue: 5
Pages: 1218-24
DOI
Related Report
Peer Reviewed
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