| Project/Area Number |
23791818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
SHIMA Tomoko 富山大学, 大学院・医学薬学研究部(医学), 助教 (00377285)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 母児免疫寛容 / 胎児(父親)抗原特異的制御性T細胞 / 父親抗原特異的制御性T細胞 / 精漿 / 妊娠維持 |
|---|
| Research Abstract |
Regulatory T（Treg） cells play an essential role for induction of feto-maternal tolerance. To understand the pathophysiology of unknown etiology of recurrent pregnancy loss and implantation failure, we have studied the paternal（fetal)antigen-specific Treg cells using mouse model. Paternal antigen specific Treg cells had paternal antigen specific immunosuppressive activity. Furthermore, paternal antigen specific Treg cells increased in the draining lymph nodes just before implantation , and in the uterus after implantation in allogeneic pregnant mice, but not in syngeneic pregnant mice.
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