Cell-to-cell communication via exosome transfer in endometrial cancer
| Project/Area Number |
23791819
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | 独立行政法人国立がん研究センター (2012)
Kanazawa University (2011) |
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Principal Investigator |
MAIDA Yoshiko 独立行政法人国立がん研究センター, 研究所, ユニット長 (20397219)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 子宮内膜癌 / exosome / microRNA / 癌 / エキソソーム |
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| Research Abstract |
Exosomes are small membrane vesicles containing various RNAs. Recent evidence suggests that human cells communicate with each other by exchanging exosomes. We found that endometrial cancer cells transmit gene regulatory small RNAs to endometrial fibroblasts using exosomes as vehicles. The results indicate a novel cell-to-cell communication between cancer cells and stromal cells via exosome transfer.
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Report
(3 results)
Research Products
(8 results)
