Molecular mechanism of progesterone synthesis by LRH-1
Project/Area Number |
23791820
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
|
Research Institution | University of Fukui |
Principal Investigator |
KAWABE Shinya 福井大学, 医学部, 特命助教 (60579415)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | LRH-1 / SF-1 / 卵巣顆粒膜細胞 / 黄体ホルモン / 黄体化 / KGN細胞 |
Research Abstract |
We determined the novel ovarian specific transcription start site and promoter region of LRH-1 in the human granulosa cells. In this study, we revealed that the expression of human LRH-1 is regulated in a tissue-specific manner, and that the novel promoter region is controlled by the Sp-family and SF-1 in ovarian granulosa cells in a coordinated fashion. Furthermore, our results suggest that gene expressioninvolved in progesterone biosynthesis is under the control of LRH-1 in human ovary.
|
Report
(3 results)
Research Products
(109 results)
-
[Journal Article] A novel isoform of liver receptor homolog-1 is regulated by steroidogenic factor-1 and the specificity protein family in ovarian granulosa cells2013
Author(s)
Kawabe, S., Yazawa, T., Kanno, M., Usami, Y., Mizutani, T., Imamichi, Y.Ju, Y., Matsumura, T., Orisaka, M., Miyamoto, K
-
Journal Title
Endocrinology
Volume: 154(4)
Pages: 1648-1660
Related Report
Peer Reviewed
-
[Journal Article] Transcriptional regulation of human ferredoxin 1 in ovarian granulosa cells2013
Author(s)
Imamichi, Y., Mizutani, T., Ju, Y., Matsumura, T., Kawabe, S., Kanno, M., Yazawa, T., Miyamoto, K.
-
Journal Title
Molecular and Cellular Endocrinology
Volume: 370
Pages: 1-10
Related Report
Peer Reviewed
-
[Journal Article] Androgen/Androgen receptor pathway regulates expression of the genes for cyclooxygenase-2 and amphiregulin in periovulatory granulosa cells2013
Author(s)
Yazawa, T., Kawabe, S., Kanno, M., Mizutani, T., Imamichi, Y., Ju, Y., Matsumura, T., Yamazaki, Y., Usami, Y., Kuribayashi, M., Shimada, M., Kitano, T., Umezawa, A., Miyamoto, K
-
Journal Title
Molecular and Cellular Endocrinology
Volume: 369
Pages: 42-51
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Nuclear receptor 5A(NR5A) family regulates 5-aminolevulinic acid synthase 1(ALAS1) gene expression in steroidogenic cells2012
Author(s)
Ju, Y., Mizutani, T., Imamichi, Y., Yazawa, T., Matsumura, T., Kawabe, S., Kanno, M., Umezawa, A., Kangawa, K., Miyamoto, K
-
Journal Title
Endocrinology
Volume: 153
Pages: 5522-5534
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Steroidogenic factor 1 (SF-1) and C/EBP β cooperatively regulate human HSD3B2 gene expression2012
Author(s)
Mizutani, T., Ju, Y., Imamichi, Y., Matsumura, T., Yazawa, T., Kawabe, S., Kanno, M., Osaki, T., Minamino, N., Umezawa, A., Miyamoto, K.
Organizer
The 15th International Congress on Hormonal Steroids and Hormones & Cancer
Place of Presentation
金沢
Related Report
-
[Presentation] A novel isoform of liver receptor homolog-1 is regulated by steroidogenic factor-1 and specificity protein (Sp) family in ovarian granulosa cells2012
Author(s)
Kawabe, S., Yazawa, T., Kanno, M., Usami, Y., Mizutani, T., Imamichi, Y., Ju, Y., Matsumura, T., Miyamoto, K
Organizer
The 15th International Congress on Hormonal Steroids and Hormones & Cancer
Place of Presentation
金沢
Related Report
-
[Presentation] Differentiation of mesenchymal stem cells and embryonic stem cells into steroidogenic cells using SF-1 and LRH-12012
Author(s)
Yazawa, T., Kawabe, S., Kanno, M., Mizutani, T., Imamichi, Y., Ju, Y., Matsumura, T., Umezawa, A., Miyamoto, K.
Organizer
The 15th International Congress on Hormonal Steroids and Hormones & Cancer
Place of Presentation
金沢
Related Report
-
[Presentation] SF-1/LRH-1 regulate a heme biosynthetic-related gene in steroidogenic cells2012
Author(s)
Ju, Y., Mizutani, T., Imamichi, Y., Matsumura, T., Yazawa, T., Kawabe, S., Kanno, M., Umezawa, A., Miyamoto, K.
Organizer
The 15th International Congress on Hormonal Steroids and Hormones & Cancer
Place of Presentation
金沢
Related Report
-
[Presentation] Transcriptional regulation offerredoxin reductase in steroidogenic cells2012
Author(s)
Imamichi, Y., Mizutani, T., Ju, Y., Matsumura, T., Yazawa, T., Kawabe, S., Kanno, M., Umezawa, A., Miyamoto, K.
Organizer
The 15th International Congress on Hormonal Steroids and Hormones & Cancer
Place of Presentation
金沢
Related Report
-
-
-
[Presentation] Identification of a novel ovarian specific isoform promoter of liver receptor homolog-1 in ovarian granulosa cells2012
Author(s)
Kawabe, S., Yazawa, T., Kanno, M., Usami, Y., Mizutani, T., Imamichi, Y., Ju, Y., Matsumura, T., Miyamoto, K
Organizer
The 94th Annual Meeting & Expo (ENDO 2012)
Place of Presentation
Houston, TEXAS,USA
Related Report
-
[Presentation] Transcriptional regulation of human FDXR gene by the transcription factor SF-12012
Author(s)
Imamichi, Y., Mizutani, T., Ju, Y., Matsumura, T., Yazawa, T., Kawabe, S., Kanno, M., Umezawa, A., Miyamoto, K
Organizer
The 94th Annual Meeting & Expo (ENDO 2012)
Place of Presentation
Houston, TEXAS,USA
Related Report
-
[Presentation] Transcriptional regulation of human 5-aminolevulinate synthase 1(ALAS1) gene in steroidogenic cells2012
Author(s)
Mizutani, T., Ju, Y., Imamichi, Y., Yazawa, T., Matsumura, T., Kawabe, S., Kanno, M., Umezawa, A., Miyamoto, K.
Organizer
The 94th Annual Meeting & Expo (ENDO 2012)
Place of Presentation
Houston, TEXAS,USA
Related Report
-
[Presentation] GSTA3 の転写調節とステロイドホルモン産生に対する役割2012
Author(s)
松村健大, 今道力敬, 水谷哲也, 具 云峰, 矢澤隆志, 菅野真史, 河邉真也, 梅澤明弘, 稲谷 大, 赤木好男, 宮本薫
Organizer
第85回日本内分泌学会学術総会
Place of Presentation
愛知
Related Report
-
[Presentation] SF-1 複合体C/EBPβ による HSD3B2 の転写調節機構の解明2012
Author(s)
水谷哲也, 具 云峰, 今道力敬, 松村健大, 矢澤隆志, 河邉真也, 菅野真史, 松浦かおる, 上木康衣, 梅澤明弘, 尾崎司, 南野直人, 宮本 薫
Organizer
第85回日本内分泌学会学術総会
Place of Presentation
愛知
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Glutatione S-transferase A3(GSTA3) プロモーター領域における転写制御2011
Author(s)
松村健大, 今道力敬, 水谷哲也, 具 云峰, 矢澤隆志, 菅野真史, 河邉真也, 梅澤明弘, 稲谷 大, 赤木好男, 宮本薫
Organizer
第34回日本分子生物学会年会
Place of Presentation
横浜
Related Report
-
[Presentation] Delta-aminolevulinate synthase 1(ALAS1) is a novel steroidogenic factor-1 (SF-1) target gene important for steroidogenesis2011
Author(s)
Ju, Y., Mizuani, T., Imamichi, Y., Matsumura, T., Yazawa, T., Kawabe, S., Kanno, M., Umezawa, A., Miyamoto, K
Organizer
第34回日本分子生物学会年会
Place of Presentation
横浜
Related Report
-
-
-
-
-
-
[Presentation] SF-1 によるクロマチン構造変換を介した新たな転写調節機構2011
Author(s)
水谷哲也, 具 云峰, 今道力敬, 松村健大, 矢澤隆志, 河邉真也, 菅野真史, 松浦かおる, 上木康衣, 梅澤明弘, 尾崎司, 南野直人, 宮本 薫
Organizer
第84回日本内分泌学会学術集会
Place of Presentation
神戸
Related Report
-
-
[Presentation] 転写因子 SF-1 の新たな標的遺伝子の同定2011
Author(s)
今道力敬, 水谷哲也, 具 云峰, 松村健大, 矢澤隆志, 河邉真也, 菅野真史, 梅澤明弘, 小亀浩一, 寒川賢治, 宮本薫
Organizer
第84回日本内分泌学会学術集会
Place of Presentation
神戸
Related Report
-
-
-
[Presentation] Transcriptional regulation of steroidogenic-related genes by SF-1 through its dependent alternations of chromatin structure2011
Author(s)
Mizutani, T., Ju, Y., Imamichi, Y., Matsumura, T., Yazawa, T., Kawabe, S., Kanno, M., Osaki, T., Minamino, N., Umezawa, A., Miyamoto, K
Organizer
Experimental Biology
Place of Presentation
Washington, DC,USA
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-