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The development of therapeutic target with system biological analysis of morphogen signals in ovarian cancer

Research Project

Project/Area Number 23791834
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKyoto University

Principal Investigator

YOSHIOKA Yumiko  京都大学, 大学院・医学研究科婦人科学産科学, 助教 (10402918)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords婦人科腫瘍学 / 卵巣癌 / BMPシグナル / 細胞増殖 / 上皮間葉移行 / 細胞増殖調節 / シグナル阻害 / 治療ターゲット / システム生物学解析 / 国際情報交流 / イギリス
Research Abstract

We would like to identify the function of BMP/SMAD5 signaling in serous ovarian cancer. The protein levels of total SMAD5 and phosphorylated SMAD5 (pSMAD5) were examined by immunohistochemical analysis using clinical serous ovarian cancer samples. Cell proliferatio is promoted by BMP signaling,otherwise suppressed by inhibiting BMP signaling, bothin vitroand in vivo.Our data suggests that BMP/SMAD5 signaling plays an important role and, therefore, becomes a potential therapeutic target in serous ovarian cancer.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Differential effects of inhibition of bone morphogenic protein(BMP) signalling on T-cell activation and differentiation2012

    • Author(s)
      Yoshioka Y, Ono M, Osaki M, Konishi I, Sakaguchi S.
    • Journal Title

      Eur J Immunol

      Volume: 42(3) Issue: 3 Pages: 749-59

    • DOI

      10.1002/eji.201141702

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors.2011

    • Author(s)
      Hamanishi J, Mandai M, Abiko K, Matsumura N, Baba T, Yoshioka Y, Kosaka K, Konishi I
    • Journal Title

      Clin Immunol

      Volume: 141 Pages: 338-347

    • NAID

      120003610113

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer -A potential therapeutic target-2012

    • Author(s)
      Peng Jin, Yumiko Yoshioka
    • Organizer
      第64回日本産婦人科学会学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer -A potential therapeutic target-2012

    • Author(s)
      Yumiko Yoshioka, Peng Jin
    • Organizer
      第10回アジア臨床腫瘍学会議
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] The Clinical Analysis of Long Term Survival after Recurrence of Epithelial Ovarian Cancer2011

    • Author(s)
      吉岡弓子、大仲恵、松村謙臣、馬場長、鈴木彩子、小阪謙三、万代昌紀、小西郁生
    • Organizer
      Asian Society of Gynecologic Oncology
    • Place of Presentation
      The Ritz-Carlton,Seoul(韓国)
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス卵巣癌細胞局所免疫における免疫抑制因子PD-L1の影響2011

    • Author(s)
      安彦郁、万代昌紀、濱西潤三、松村謙臣、馬場長、岡本尊子、吉岡弓子、山村省吾、姜 賢淑、奈倉 道和、小阪 謙三、小西 郁生
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場、リーガロイヤルホテル大阪(大阪市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 進行卵巣癌に対する化学療法は,腫瘍局所の免疫状態を変化させる2011

    • Author(s)
      濱西潤三、万代昌紀、松村謙臣、馬場長、山村省吾、吉岡弓子、姜賢淑、安彦郁、奈倉道和、小阪謙三、小西郁生
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場、リーガロイヤルホテル大阪(大阪市)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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