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Modulation of a novel estrogen receptor signaling in uterine endometrial cancer

Research Project

Project/Area Number 23791849
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

MORI Taisuke  京都府立医科大学, 医学研究科, 助教 (00569824)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords子宮内膜癌 / エストロゲン関連受容体 / タモキシフェン / ホルモン療法 / 子宮体癌 / ホルモン依存性腫瘍 / エストロゲン受容体
Research Abstract

We aimed to measure the expression of ERRγ and determine its association with the ER-mediated pathway in human endometrial cancer. The relationship between ERRγ and ERαstatus could be a predictive marker for the treatment of uterine endometrial cancer,which provides an impetus for the identification of ligands for nuclear orphan receptor ERRγ

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (11 results) Book (2 results)

  • [Journal Article] Premature delivery due to intrauterine candida infection that caused neonatal congenital cutaneous candidiasis; a case report.2013

    • Author(s)
      Ito F, Okubo T, Yasuo T, Mori T, Iwasa K, Iwasaku K, Kitawaki J.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 39 Pages: 341-343

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of fertility-sparing treatment with medoxyprogesterone acetate for atypical hyperplasia and endometrial carcinoma in young Japanese women2013

    • Author(s)
      Kataoka H, Mori T, Yamamoto T, Sawada M, Kuroboshi H, Tatsumi H, Iwasaku K, Kitawaki J
    • Journal Title

      Eur J Gynaecol Oncol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of primary prophylaxis with granulocyte colony-stimulating gfactor for ovarian cancer.2013

    • Author(s)
      Matsui K, Mori T, Sawada M, Kuroboshi H, Tatsumi H, Yoshioka T, Akiyama M, Yamamoto T, Iwasaku K, Kitawaki J.
    • Journal Title

      2013 Eur J Gyanecol Oncol In press.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clear cell adenocarcinoma of the ovary with a sarcoid reaction in the spleen and regional lymph nodes; A case report2013

    • Author(s)
      Matsushima H, Mori T, Tsuchiya H, Ooshima K, Kitawaki J
    • Journal Title

      2013 Gynecol Oncol Report

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 当院における婦人科悪性腫瘍手術時の創閉鎖の工夫と検討2012

    • Author(s)
      竹原也惠、森泰輔、澤田守男、黒星晴夫、辰巳弘、岩破一博、北脇城
    • Journal Title

      産婦人科の進歩

      Volume: 64 Pages: 101-125

    • NAID

      130001890017

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen-related receptor gamma regulates estrogen receptor responsiveness in uterine endometrialcancer2012

    • Author(s)
      Yamamoto T, Mori T, Sawada M, Kuroboshi H, Tatsumi H, Matsushima H, Iwasaku K, Kitawaki J.
    • Volume
      22
    • Pages
      1509-1516
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer.2012

    • Author(s)
      Takuro Yamamoto
    • Journal Title

      International Journal of Gynecologic Cancer

      Volume: 22 Issue: 9 Pages: 1509-1516

    • DOI

      10.1097/igc.0b013e31826fd623

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Baicalin increases VEGF expression and angiogenesis by activating the ERR alpha/PGC-1 alpha pathway2011

    • Author(s)
      Zhang K, Lu J, Mori T, Smith-Powell L, Synold TW, Chen S, Wen W.
    • Journal Title

      Cardiovascular Research

      Volume: 89 Pages: 426-435

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoepithelial-like carcinoma of the uterine cervix; a case report.2011

    • Author(s)
      Mori T, Sawada M, Matsuo S, Kuroboshi H, Tatsumi H, Iwasaku K, Kitawaki J
    • Journal Title

      Eur J Gynaecol Oncol

      Volume: 32 Pages: 325-327

    • NAID

      130001222823

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen-related receptor alpha expression and function are associated with VEGF in human cervical cancer.2011

    • Author(s)
      Mori T, Sawada M, Kuroboshi H, Tatsumi H, Katsuyama M, Iwasaku K, Kitawaki J
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21 Pages: 609-615

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 外陰癌根治術後の外陰部再検に臀溝皮弁を用いた 1例2011

    • Author(s)
      山本拓郎、澤田守男、黒星晴夫、辰巳弘、森泰輔、岩破一博、北脇城
    • Journal Title

      産婦人科の進歩

      Volume: 63 Pages: 33-36

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen-related receptor α expression and function are associated with vascular endothelial growth factor in human cervical cancer2011

    • Author(s)
      Mori T, Sawada M, Kuroboshi H, Tatsumi H, Katsuyama M, Iwasaku K, Kitawaki J.
    • Journal Title

      International Journal of Gynecological Cancer

      Volume: 21 Pages: 609-615

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ERRγは子宮体癌においてERαを介したエストロゲン応答を調節し増殖に関与する2013

    • Author(s)
      山本拓郎
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      日本、札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Estrogen-related receptor expression and function are associated with VEGF in human cervical cancer2012

    • Author(s)
      Mori T
    • Organizer
      15th International Congress on hormonal steroids and hormones and cancer.
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2012-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] PGC-1alpha is involved in local estrogen biosynthesis in ovarian endometrioma.2012

    • Author(s)
      Suganuma I, Mori T, Matsuo S, Tanaka Y, Sasaki A, Ito F, Kusuki I, Iwasaku K, Kitawaki J
    • Organizer
      Asian endometriosis conference
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2012-11-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 婦人科腫瘍原発巣および所属リンパ節におけるパクリタキセルの薬物動態的検討2012

    • Author(s)
      森泰輔
    • Organizer
      婦人科腫瘍原発巣および所属リンパ節におけるパクリタキセルの薬物動態的検討
    • Place of Presentation
      京都
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ERRγは子宮体癌において ERγを介したエストロゲン応答を調節し増殖に関与する2012

    • Author(s)
      山本拓郎、森泰輔、北脇城
    • Organizer
      第30回日本ヒト細胞学会
    • Place of Presentation
      大阪
    • Year and Date
      2012-08-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 婦人科腫瘍原発巣および所属リンパ節におけるパクリタキセルの薬物動態的検討2012

    • Author(s)
      森泰輔、澤田守男、山本拓郎、北脇城
    • Organizer
      第30回ヒト細胞学会
    • Place of Presentation
      大阪
    • Year and Date
      2012-08-18
    • Related Report
      2012 Final Research Report
  • [Presentation] ERRγは子宮体癌において Erαを介したエストロゲン応答を調節し増殖に関与する2012

    • Author(s)
      山本拓郎、森泰輔、澤田守男、黒星晴夫、辰巳弘、吉岡崇、秋山誠、岩破一博、北脇城
    • Organizer
      第52回日本婦人科腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] パクリタキセルは婦人科腫瘍原発巣には有効だがリンパ節には効かない2012

    • Author(s)
      森泰輔、澤田守男、黒星晴夫、辰巳弘、小柴寿人、野口敏史、岩破一博、北脇城
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Neoadjuvant weekly carboplatin and paclitaxel followed by radical hysterectomy for localy advanced cervical cancer-long term result.2011

    • Author(s)
      Mori T, Sawada M, Kuroboshi H, Tatsumi H, Iwasaku K, Kitawaki J
    • Organizer
      2nd Biennial meeting of Asian Society of Gynecologic Oncology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-11-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 卵巣癌における G-CSF 一次投与の有用性についての検討2011

    • Author(s)
      森泰輔
    • Organizer
      第7回鴨和感染症フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2011-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮頸癌に対する術前化学療法 weeklyTC の治療効果と予後についての検討2011

    • Author(s)
      森泰輔、澤田守男、黒星晴夫、辰巳弘、岩破一博、北脇城
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2012 Final Research Report
  • [Book] 当院における婦人科悪性腫瘍手術時の創閉鎖の工夫と検討2012

    • Author(s)
      森泰輔
    • Publisher
      Allegro 6巻 1-2
    • Related Report
      2012 Final Research Report
  • [Book] タキサン/ プラチナ製剤に過敏反応を示す進行卵巣癌に GC(ゲムシタビン+カルボプラチン)療法を使用した 1例

    • Author(s)
      森泰輔
    • Publisher
      Treatment of ovarian cancer 1-2
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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