| Project/Area Number |
23791850
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 婦人科腫瘍学 / 卵巣がん / 樹状細胞 / NKT細胞 / 免疫 / がん |
|---|
| Research Abstract |
The present study investigated the role of human iNKT cells in the regulation of Osteopontin (OPN)production by dendritic cells (DCs). The activation of iNKT cells by their specific ligand α-galactosylceramide inhibitsthe OPN production byDCs. The downregulation of OPN is associated with a production of IL-4, IL-13, and IFN-γfrom iNKT cells. These findings indicate that iNKT cells modify the DC functionto suppress the OPN-dependent inflammatory condition that promotes the tumor development
|
