Development of a new immunotherapy for ovarian cancer by utilizing the cytotoxic effects and adjuvant properties of natural killer T cells
Project/Area Number |
23791850
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Saitama Medical University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 婦人科腫瘍学 / 卵巣がん / 樹状細胞 / NKT細胞 / 免疫 / がん |
Research Abstract |
The present study investigated the role of human iNKT cells in the regulation of Osteopontin (OPN)production by dendritic cells (DCs). The activation of iNKT cells by their specific ligand α-galactosylceramide inhibitsthe OPN production byDCs. The downregulation of OPN is associated with a production of IL-4, IL-13, and IFN-γfrom iNKT cells. These findings indicate that iNKT cells modify the DC functionto suppress the OPN-dependent inflammatory condition that promotes the tumor development
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells.2011
Author(s)
Kajihara, T., Uchino, S., Suzuki, M., Itakura, A., Brosens, J.J., Ishihara, O.
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Journal Title
Fertil. Steril.
Volume: 95
Pages: 1302-1307
Related Report
Peer Reviewed
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