An individual diagnosis of uterine cancer stem cells by SNP analysis

• Project/Area Number: 23791854
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: NOMURA HIROYUKI 慶應義塾大学, 医学部, 助教 (50327590)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 一塩基多型 / 化学療法 / 効果予測 / 子宮体癌 / 卵巣癌

Research Abstract

Single nucleotide polymorphisms (SNPs) analysis is expected as the personalized medicine in pharmacotherapy. In this study, we attempted to extract SNPs correlated with drug response of adjuvant chemotherapy for uterine cancer as an individual diagnosis of cancer stem cells.
A comprehensive SNP analysis was conducted, and specific SNPs on drug metabolism genes were identified. These SNPs may be useful in predicting toxicities as well as effects of chemotherapy.
An individual diagnosis of cancer stem cells based on genomic information could apply to a new personalized treatment for uterine and other cancers.

Research Products

• [Journal Article] 子宮体がんの術後再発リスク評価と術後療法 (2013)
  • Author(s): 進伸幸,山上亘,野村弘行,阪埜浩司,青木大輔
  • Journal Title: 臨床婦人科産科 Volume: 67 Pages: 474-484
• [Journal Article] Current status of molecular-targeted drugs for endometrial cancer (Review) (2013)
  • Author(s): Nogami Y, Banno K, Kisu I, Yanokura M, Umene K, Masuda K, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
  • Journal Title: Mol Clin Oncol Volume: 1 Issue: 5 Pages: 799-804
  • DOI: 10.3892/mco.2013.140
• [Journal Article] Current status of molecular-targeted drugs for endometrial cancer (Review) (2013)
  • Author(s): Nogami Y, Banno K, Kisu I, Yanokura M, Umene K, Masuda K, Kobayashi Y, Yamagami W, Nomura H,Tominaga E, Susumu N, Aoki D
  • Journal Title: Molecular and Clinical Oncology Volume: 1 Pages: 799-804
• [Journal Article] Biomarkers in endometrial cancer : Possible clinical applications (Review) (2012)
  • Author(s): Banno k, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
  • Journal Title: Oncol Lett Volume: 3 Issue: 6 Pages: 1175-1180
  • DOI: 10.3892/ol.2012.654
• [Journal Article] 発現解析による子宮体癌の再発予測モデルの開発 (2012)
  • Author(s): 津田浩史,井口蓉子,片岡史夫,野村弘行,田中英雄,千代田達幸,平沢晃,進伸幸,青木大輔
  • Journal Title: 日本分子腫瘍マーカー研究会誌 Volume: 27 Pages: 45-46
  • NAID: 130004436451
• [Journal Article] Role of circulating free alu DNA in endometrial cancer (2012)
  • Author(s): Tanaka H, Tsuda H, Susumu N, et al.
  • Journal Title: Int J Gynecol Cancer Volume: 22 Issue: 1 Pages: 82-86
  • DOI: 10.1097/igc.0b013e3182328c94
  • Peer Reviewed
• [Presentation] 上皮性卵巣癌に対するTC療法の薬物反応を規定する一塩基多型の抽出 (2014)
  • Author(s): 野村弘行,片岡史夫,岩佐尚美,中平直希,橋本志歩,有馬宏和,千代田達幸,山上亘,冨永英一郎,進伸幸,吉村泰典,青木大輔
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2014-04-19
• [Presentation] 上皮性卵巣癌に対するTC療法の薬物反応を規定する一塩基多型の抽出 (2014)
  • Author(s): 野村 弘行，片岡 史夫，岩佐 尚美，中平 直希，橋本 志歩，有馬 宏和，千代田 達幸，山上 亘，冨永 英一郎，進 伸幸，吉村 泰典，青木 大輔
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京都
• [Presentation] Association between drug response and gene polymorphisms in first-line chemotherapy for ovarian cancer (2013)
  • Author(s): Nomura H , Kataoka F, Chiyoda T, Tanaka H, Hashimoto S, Arima H, Yamagami W, Tominaga E, Susumu N, Aoki D
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2013-10-05
• [Presentation] 子宮体癌up date (2013)
  • Author(s): 野村弘行
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2013-08-30
• [Presentation] 上皮性卵巣癌初回化学療法における治療効果予測因子としてのgene polymorphismsの解析 (2013)
  • Author(s): 野村弘行,津田浩史,片岡史夫,千代田達幸,井口蓉子,橋本志歩,山上亘,冨永英一郎,進伸幸,青木大輔,吉村泰典
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2013-05-10
• [Presentation] 当院における子宮体癌IVb期症例の臨床病理学的検討 (2012)
  • Author(s): 滝川彩,山上亘,進伸幸,桑波田美智子,野村弘行,片岡史夫,冨永英一郎,阪埜浩司,津田浩史,青木大輔,吉村泰典
  • Organizer: 第124回関東連合産科婦人科学会学術集会
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2012-10-28
• [Presentation] 上皮性卵巣癌における初回化学療法のprognostic markerとしての血液毒性 (2012)
  • Author(s): 野村弘行,津田浩史,片岡史夫,田中京子,千代田達幸,山上亘,平沢晃,冨永英一郎,進伸幸,青木大輔
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2012-10-28
• [Presentation] (2012)
  • Author(s): Chiyoda T, Tsuda H, Ito Y, Tanaka H, Takano M, Nishimura S, Kataoka F, Nomura H, Hirasawa A, Susumu N, Aoki D
  • Organizer: Biennial Meeting of the International Gynecologic Cancer Society (IGCS)
  • Place of Presentation: Vancourver, Canada
  • Year and Date: 2012-10-13
• [Presentation] Classification of ovarian cancer based on the stromal gene expression related with recurrence of endometrial cancer (2012)
  • Author(s): Tsuda H, Ito Y, Kataoka F, Tanaka H, Nomura H, Chiyoda T, Iguchi Y, Hirasawa A, Tominaga E, Yamagami W, Susumu N, Aoki D
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2012-09-21
• [Presentation] 子宮体癌および上皮性卵巣癌症例における血漿中遊離DNA量に関する検討 (2012)
  • Author(s): 野村弘行,津田浩史,片岡史夫,千代田達幸,井口蓉子,山上亘,冨永英一郎,進伸幸,青木大輔,吉村泰典
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2012-04-13
• [Presentation] 子宮体癌の再発を予測できる間質遺伝子の発現に基づいた卵巣癌症例のグループ化 (2012)
  • Author(s): 津田 浩史、野村 弘行、片岡 史夫、千代田 達幸、冨永 英一郎、山上 亘、進 伸幸、青木 大輔
  • Organizer: 第32回日本分子腫瘍マーカー研究会
  • Place of Presentation: 北海道札幌市
• [Presentation] A gene expression profile as a predictor of recurrence in low and intermediate-risk endometrial cancer (2011)
  • Author(s): Tsuda H, Ito Y, Tanaka H, Takano M,Nishimura S, Kataoka F, Nomura H, Chiyoda T, Hirasawa A, Susumu N, Aoki D
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2011-10-05
• [Presentation] The significance of measurement of cell free DNA in the endometrial cancer (2011)
  • Author(s): Tanaka H, Tsuda H, Nomura H, Kataoka F, Hirasawa A, Chiyoda T, Susumu N, Aoki D
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2011-10-03
• [Presentation] 発現解析による子宮体癌の再発予測モデルの開発 (2011)
  • Author(s): 津田浩史,井口蓉子,片岡史夫,野村弘行,田中英雄,千代田達幸,平沢晃,進伸幸,青木大輔
  • Organizer: 第31回日本分子腫瘍マーカー研究会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2011-10-02
• [Presentation] 子宮体部癌肉腫の遺伝子発現パターンに基づいた治療戦略の考察 (2011)
  • Author(s): 千代田達幸,津田浩史,野村弘行,片岡史夫,平沢晃,進伸幸,青木大輔,吉村泰典
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2011-08-30
• [Presentation] 発現解析による子宮体癌の再発予測モデルの開発 (2011)
  • Author(s): 津田浩史、井口蓉子、片岡史夫、野村弘行、田中英雄、千代田達幸、平沢晃、進伸幸、青木大輔
  • Organizer: 日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Book] CANCER OF THE UTERINE ENDOMETRIUM - ADVANCES AND CONTROVERSIES (2012)
  • Author(s): Susumu N, Nomura H, Yamagami W, Hirasawa A, Banno K, Tsuda H, Sagae S, Aoki D
  • Publisher: In Tech (Croatia)
• [Remarks]
  • URL: http://www.obgy.med.keio.ac.jp/04research/06gy2.html