The roles of PKC in regulating the function of placenta-specifictranscription factor GCMa/1

• Project/Area Number: 23791858
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kinjo Gakuin University
• Principal Investigator: YUKO Yasui 金城学院大学, 付置研究所, その他 (80434554)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: GCMa(GCM1) / 胎盤 / GCM / GCMa/GCM1 / 転写因子

Research Abstract

Serines 328, 378 and 383 on GCMa are phosphorylated by the PKC- and MEK-dependent signaling pathway. The phosphorylation of GCMa contributes to enhance its degradationby increase of the ubiquitination level as well as its transcriptional activity.

Research Products

• [Journal Article] PMA induces GCMaphosphorylation and alters its stability via the PKC- and ERK-dependent pathway. (2012)
  • Author(s): Y.YASUI, D.MIYAZAWA, H.UEDA, K.SATO,Y.KITADE and K.YAMADA.
  • Journal Title: Biomedical Research Volume: 33 Pages: 217-224
  • Peer Reviewed
• [Journal Article] PMA induces GCMaphosphorylation and alters its stability via the PKC- and ERK-dependent pathway. (2012)
  • Author(s): Y.YASUI, K.YAMADA, S.TAKAHASHI, M.SUGIURA-OGASAWARA, K.SATO, D.MIYAZAWA, T.SUGIYAMA, Y.KITADE and H.UEDA.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 417 Pages: 1127-1132
  • Peer Reviewed
• [Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr. (2012)
  • Author(s): Kitamori K
  • Journal Title: Environ Health Prev Med. Volume: May;17(3) Issue: 3 Pages: 173-82
  • DOI: 10.1007/s12199-011-0235-9
  • NAID: 10030616942
  • Peer Reviewed
• [Journal Article] PMA-induced GCMa phosphorylation stimulates its transcriptional activity and degradation (2012)
  • Author(s): Yuko Yasui, Daisuke Miyazawa, Hiroshi Ueda, Katsuya Sato, Yukio Kitade, Kazuyo Yamada
  • Journal Title: Biomedical Research Volume: 33 Issue: 6 Pages: 217-224
  • DOI: 10.1128/mbio.00410-12
  • NAID: 130004470824
  • Peer Reviewed
• [Journal Article] PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway. (2012)
  • Author(s): Y. Yasui, K. Yamada, S. Takahashi, M. Sugiura-Ogasawara, K. Sato, D. Miyazawa, T. Sugiyama, Y. Kitade and H. Ueda
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 417 Pages: 1127-1132
  • Peer Reviewed
• [Journal Article] Gs and Gq signalings regulate hPEM-2-induced cell responses in Neuro-2a cells. (2011)
  • Author(s): R. Nagae, K. Sato, Y. Yasui, Y. Banno, T. Nagase and H. Ueda
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 415 Pages: 168-173
  • Peer Reviewed
• [Journal Article] Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice. (2011)
  • Author(s): D. Miyazawa, Y. Yasui, K. Yamada, N. Ohara, H. Okuyama
  • Journal Title: Biomedical Research Volume: 32 Pages: 237-245
  • Peer Reviewed
• [Presentation] 胎盤特異的転写因子GCMa/1のPMAによる発現調節機構〓リン酸化部位の同定 (2011)
  • Author(s): 安井裕子
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] 胎盤特異的転写因子GCMa/1の発現調節機構における新規リン酸化部位の同定 (2011)
  • Author(s): 安井裕子
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 金城学院大学
  • Year and Date: 2011-07-09
• [Presentation] 菜種（カノーラ）油摂取が脳卒中易発症高血圧自然発症ラット（SHRSP）の病態悪化を促進する機序
  • Author(s): 小野田早恵、内藤由紀子、立花滋博、河村さやか、大原直樹、吉川真衣、新美まどか、川口真帆、宮澤大介、安井裕子、山田和代、奥山治美
  • Organizer: 日本毒性学会年会
  • Place of Presentation: 仙台国際センター
• [Presentation] 異なる種類の高脂肪食がラット褐色脂肪組織の生化学指標に及ぼす影響
  • Author(s): 山田英里、津島宏美、森（河辺）真由美、宮澤大介、安井裕子、奥山治美、山田和代
  • Organizer: 日本脂質栄養学会 第21回大会
  • Place of Presentation: 麻布大学 神奈川県
• [Presentation] 胎盤特異的転写因子GCMa/1の発現調節機構における新規リン酸化部位の同定
  • Author(s): 安井裕子、山田和代、宮澤大介、大橋彩乃、北出幸夫、上田浩
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 金城学院大学
• [Presentation] 胎盤特異的転写因子GCMa/1のPMAによる発現調節機構－リン酸化部位の同定－
  • Author(s): 安井裕子、山田和代、宮澤大介、大橋彩乃、北出幸夫、上田浩
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] ミニブタ組織のステロイドホルモンに対する植物油脂長期投与の影響
  • Author(s): 宮澤大介、大原直樹、桜井杏、安井裕子、北森一哉、斉藤義明、臼見憲司、山田和代、今井 唯、山田英里、大橋彩乃、水谷友香、野々垣常正、小林身哉、奥山治美
  • Organizer: 日本脂質栄養学会 第20回大会
  • Place of Presentation: 女子栄養大学
• [Presentation] 植物油脂長期投与によるミニブタ組織のステロイドホルモンへの影響
  • Author(s): 宮澤大介、大原直樹、桜井杏、安井裕子、北森一哉、斉藤義明、臼見憲司、山田和代、今井 唯、山田英里、大橋彩乃、水谷友香、野々垣常正、小林身哉、奥山治美
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館