| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We performed a retrospective analysis of the association between tumour HPV status and the demographic and clinicopathological parameters of 71 patients with oropharyngeal squamous cell carcinoma. Of the 71 patients, 23 were HPV-positive. Kaplan-Meier survival analysis showed improved overall survival rates in patients with HPV-positive tumours compared with HPV-negative tumours. Of the 45 patients received chemoradiotherapy, HPV-positive patients experienced better overall survival than HPV-negative patients. We performed a retrospective analysis of the association between p16 expression and HPV status. Of the 91 patients, 29 were HPV-positive and 31 were p16-positive. The 3-year overall survival rates were 82.2% in the p16-positive subgroup and 65.1% in the p16-negative subgroup. Our results showed that the patients with HPV-/p16+ had poor prognosis as compared with the patients with HPV+/p16+, therefore p16 IHC alone may not be a perfect surrogate marker for HPV infection.
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