Expression of the MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma
Project/Area Number |
23791868
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
|
Research Institution | Asahikawa Medical College |
Principal Investigator |
KISHIBE Kan 旭川医科大学, 医学部, 助教 (80447101)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 鼻性NK/T細胞リンパ腫 / Epstein-Barr virus / マイクロRNA / mir-15a / NK/T細胞リンパ腫 / EBV / 悪性リンパ腫 / 耳鼻咽喉科 / 頭頸部腫瘍 |
Research Abstract |
We found that microRNA (miR)-15a was expressed at a much lower level in Nasal NK/T cell lymphoma (NNKTL) cells than in normal peripheral NK-cells and EBV-negative NK-cell line KHYG-1. In NNKTL, down-regulation of miR-15a possibly due to LMP1 implicates in the pathogenesis of NNKTL through cell proliferation via enhancing expressions of the targeting MYB and cyclin D1.
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Report
(3 results)
Research Products
(19 results)