Expression of the MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma

• Project/Area Number: 23791868
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Asahikawa Medical College
• Principal Investigator: KISHIBE Kan 旭川医科大学, 医学部, 助教 (80447101)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 鼻性NK/T細胞リンパ腫 / Epstein-Barr virus / マイクロRNA / mir-15a / NK/T細胞リンパ腫 / EBV / 悪性リンパ腫 / 耳鼻咽喉科 / 頭頸部腫瘍

Research Abstract

We found that microRNA (miR)-15a was expressed at a much lower level in Nasal NK/T cell lymphoma (NNKTL) cells than in normal peripheral NK-cells and EBV-negative NK-cell line KHYG-1. In NNKTL, down-regulation of miR-15a possibly due to LMP1 implicates in the pathogenesis of NNKTL through cell proliferation via enhancing expressions of the targeting MYB and cyclin D1.

Research Products

• [Journal Article] 【HPV・EBVと頭頸部腫瘍】 EBVと悪性リンパ腫 (2012)
  • Author(s): 岸部 幹、原渕 保明
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 84(9) Pages: 655-661
• [Journal Article] 唾液腺腫瘍-診療所で可能な鑑別診断-悪性リンパ腫、MTX関連リンパ増殖性疾患 (2012)
  • Author(s): 岸部 幹、原渕 保明
  • Journal Title: ENTONI Volume: 148 Pages: 52-58
  • NAID: 120005365962
• [Journal Article] Expression of CD70 in nasal natural killer/T cell lymphoma cell lines and patients; its role for cell proliferation through binding to soluble CD27 (2012)
  • Author(s): Yoshino K, Kishibe K, Nagato T, Ueda S, Komabayashi Y, Takahara M, Harabuchi Y
  • Journal Title: Br J Haematol Volume: 160(3) Pages: 331-42
  • Peer Reviewed
• [Journal Article] 【HPV・EBVと頭頸部腫瘍】 EBVと悪性リンパ腫 (2012)
  • Author(s): 岸部 幹
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 84 Pages: 655-661
• [Journal Article] 【唾液腺腫瘍-診療所で可能な鑑別診断-】 悪性リンパ腫、MTX関連リンパ増殖性疾患 (2012)
  • Author(s): 岸部 幹
  • Journal Title: ＥＮＴＯＮＩ Volume: 148 Pages: 52-58
  • NAID: 120005365962
• [Journal Article] Expression of CD70 in nasal natural killer/T cell lymphoma cell lines and patients; its role for cell proliferation through binding to soluble CD27. (2012)
  • Author(s): Kazumi Yoshino
  • Journal Title: Br J Haematol. Volume: 160 Issue: 3 Pages: 331-342
  • DOI: 10.1111/bjh.12136
  • Peer Reviewed
• [Journal Article] 鼻副鼻腔疾患におけるウイルス感染の位置づけ 鼻性NK/T細胞リンパ腫の発症・増殖におけるEBウイルスの関与 (2011)
  • Author(s): 岸部 幹
  • Journal Title: 日本鼻科学会会誌 Volume: 50(1) Pages: 87-90
  • NAID: 120004461846
• [Journal Article] 鼻副鼻腔疾患におけるウイルス感染の位置づけ 鼻性NK/T細胞リンパ腫の発症・増殖におけるEBウイルスの関与 (2011)
  • Author(s): 岸部 幹
  • Journal Title: 日本鼻科学会会誌 Volume: 50 Pages: 87-90
  • NAID: 120004461846
• [Presentation] 鼻性NK/T 細胞リンパ腫におけるEB ウイルスmicroRNA の発現と機能解析 (2013)
  • Author(s): 岸部 幹,駒林 優樹,熊井 琢美,高原 幹,林 達哉,原渕 保明
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 倉敷市
• [Presentation] Expression of MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma Cell Lines (2012)
  • Author(s): Kishibe K, Komabayashi Y, Nagato T, Takahara M, Harabuchi Y
  • Organizer: EBV 2012
  • Place of Presentation: Philadelphia, USA
• [Presentation] 鼻性NK/T 細胞リンパ腫におけるEB ウイルスmicroRNA の発現と機能解析 (2012)
  • Author(s): 岸部 幹,駒林 優樹,長門 利純、高原 幹,林 達哉,原渕 保明
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大津市
• [Presentation] Expression of MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma Cell Lines (2012)
  • Author(s): Kishibe K, Komabayashi Y, Yoshino K, Nagato T, Takahara M, Katayama K, Harabuchi Y
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] 鼻性NK/T細胞リンパ腫におけるmicroRNAの発現 (2012)
  • Author(s): 岸部 幹//吉野和美//長門利純//高原 幹//片山昭公//林 達哉//原渕保明
  • Organizer: 日本耳鼻咽喉科免疫アレルギー
  • Place of Presentation: 大分
• [Presentation] Expression of MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma Cell Lines (2011)
  • Author(s): Kishibe K, Komabayashi Y, Yoshino K, Nagato T, Takahara M, Katayama K, Hayashi T, Harabuchi Y
  • Organizer: 15^<th> International Congress of Virology
  • Place of Presentation: Sapporo
• [Presentation] Expression of MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma Cell Lines (2011)
  • Author(s): Kishibe K, Komabayashi Y, Yoshino K, Nagato T, Takahara M, Katayama K, Hayashi T, Harabuchi Y., Harabuchi Y.
  • Organizer: 30th IRS-ISIAN 2011
  • Place of Presentation: Tokyo
• [Presentation] 鼻性NK/T 細胞リンパ腫におけるEB ウイルスmicroRNA の発現と機能解析 (2011)
  • Author(s): 岸部 幹,吉野 和美,長門 利純、高原 幹,片山 昭公、林 達哉,原渕 保明
  • Organizer: 第29回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大分市
• [Presentation] Expression of MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma Cell Lines (2011)
  • Author(s): Kishibe,K.//Komabayashi, Y.//Yoshino,K.//Nagato,T.//Takahara,M.//Katayama,K.//Harabuchi,Y.
  • Organizer: 日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] Expression of MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma Cell Lines (2011)
  • Author(s): Kishibe,K.//Komabayashi, Y.//Yoshino,K.//Nagato,T.//Takahara,M.//Katayama,K.//Hayashi,T.//Harabuchi,Y.
  • Organizer: International Congress of Virology
  • Place of Presentation: 札幌
• [Presentation] Expression of MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma Cell Lines (2011)
  • Author(s): Kishibe,K.//Komabayashi, Y.//Yoshino,K.//Nagato,T.//Takahara,M.//Katayama,K.//Hayashi,T.//Harabuchi,Y.
  • Organizer: IRS-ISIAN2011
  • Place of Presentation: 東京