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Changing of the firing properties of vestibular neurons induced by temporal circulation ischemia

Research Project

Project/Area Number 23791874
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionGunma University

Principal Investigator

TAKAYASU Yukihiro  群馬大学, 医学部附属病院, 講師 (70375533)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords前庭神経核 / 虚血 / パッチクランプ / 前庭小脳 / めまい平衡 / 前庭神経
Research Abstract

The purpose of this study is clarifying the changing of the firing properties of central vestibular neurons induced by temporal circulation ischemia. We use perfusion system of Oxygen-Glucose Deprivated external solution for acute brain slices of the rat to mimic the ischemic insult. At beginning, we tested spontaneous firings in neurons in the vestibular nucleus in rat acute slices of brainstem using whole-cell patch-clamp recording. Vestibular neurons were current-clamped. Next, we applied Oxygen-Glucose Deprivated external solution. The firings of vestibular neurons were decreased during ischemic stimulation. This result indicated that vestibular neurons were hyperpolarized by Oxygen-Glucose Deprivation (ODG). The mechanisms underlying the hyperpolarization of vestibular neurons are thought to be OGD-induced changing of the membrane properties of cation permeability and increase in inhibitory inputs from presynaptic neurons.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Improvement of tracheal flap method for laryngotracheal separation2013

    • Author(s)
      Shino Masato, Yasuoka Yoshihito, Murata Takaaki, Ninomiya Hirosi, Takayasu Yukihiro, Takahashi Kastumasa, Chikamatsu Kazuaki
    • Journal Title

      Laryngoscope

      Volume: 123 Pages: 440-445

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of tracheal flap method for laryngotracheal separation.2013

    • Author(s)
      Shino Masato, Yasuoka Yoshihito, Murata Takaaki, Ninomiya Hirosi, Takayasu Yukihiro, Takahashi Kastumasa, Chikamatsu Kazuaki
    • Journal Title

      Laryngoscope

      Volume: 123 Pages: 440-445

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 群馬大学における頭頸部非扁平上皮癌に対する重粒子線治療成績2013

    • Author(s)
      高安幸弘、紫野正人、豊田実、高橋克昌、近松一朗
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 群馬大学における頭頸部非扁平上皮癌に対する重粒子線治療成績2013

    • Author(s)
      高安幸弘、紫野正人、豊田実、高橋克昌、近松一朗
    • Organizer
      第114回 日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 無酸素無グルコース刺激によるNMDA受容体を介した前庭小脳unipolar brush cellの自発発火の増強2012

    • Author(s)
      高安幸弘、紫野正人、斎藤彩子、岡宮智史、高橋克昌、宮下元明、古屋信彦
    • Organizer
      第71回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Ischemia-induced transient enhancement of spontaneous excitatory synaptic events in Purkinje cells in the uvula-nodulus depend on regional distinction of excitability in granule cells and unipolar brush cells2012

    • Author(s)
      Takayasu Yukihiro, Shino Masato, Chikamatsu Kazuaki
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Oreleans, USA
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 診断に苦慮している難治性頭位めまいの1症例2012

    • Author(s)
      高安幸弘、高橋克昌、岡宮智史、宮下元明、近松一朗
    • Organizer
      第101回日本耳鼻咽喉科学会群馬県地方部会学術講演会
    • Place of Presentation
      前橋
    • Year and Date
      2012-07-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 群馬大学耳鼻咽喉科における重粒子線治療の経過報告~悪性黒色腫症例以外を中心に~2012

    • Author(s)
      高安幸弘、紫野正人、豊田実、高橋克昌、近松一朗、白井克幸、齊藤淳一、大野達也、中野隆史
    • Organizer
      第100回日本耳鼻咽喉科学会群馬県地方部会学術講演会
    • Place of Presentation
      前橋
    • Year and Date
      2012-04-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Ischemia-induced transient enhancement of spontaneous excitatory synaptic events in Purkinje cells in the uvula-nodulus depend on regional distinction of excitability in granule cells and unipolar brush cells2012

    • Author(s)
      高安幸弘
    • Organizer
      Neuroscience 2012 (北米神経科学会)
    • Place of Presentation
      ニューオリンズ(アメリカ合衆国)
    • Related Report
      2012 Research-status Report
  • [Presentation] 無酸素無グルコース刺激によるNMDA受容体を介した前庭小脳unipolar brush cellの自発発火の増強2012

    • Author(s)
      高安幸弘
    • Organizer
      第71回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 前庭小脳unipolar brush cellにおける発火特徴と無酸素無グルコース刺激に対する感受性2011

    • Author(s)
      高安幸弘、紫野正人、古屋信彦
    • Organizer
      第70回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 前庭小脳unipolar brush cellにおける発火特徴と無酸素無グルコース刺激に対する感受性2011

    • Author(s)
      高安幸弘
    • Organizer
      第70回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      ホテルニューオータニ幕張(千葉県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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