| Project/Area Number |
23791876
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
KIKKAWA Naoko 千葉大学, 医学部附属病院, 医員 (50400924)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | (1)頭頸部癌 / (2)マイクロRNA / 頭頸部癌 / マイクロRNA |
|---|
| Research Abstract |
MicroRNAs (miRNAs) are a class of small non-coding cRNA molecules of 19-22 nucleotides that regulate protein-coding gene expression by repressing translation or cleaving RNA transcripts in a sequence-specific manner. A growing body of evidence suggests that miRNAs are aberrantly expressed in several types of human cancer, and that they play significant roles in the initiation, progression and metastasis of human cancers. The results of the miRNA expression signatures of hypo-pharyngeal and esophageal squamous cell carcinoma indicated that miR-218 was downregulated in cancer cells and suggested as a tumor suppressive miRNA. Gain-of-function assays demonstrated that miR-218 inhibited cancer cell proliferation and invasion through targeting LAMB3. The LAMB3 are an important and biologically active part of the basal lamina, influencing cell differentiation, migration,adhesion, proliferation, and survival.
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