Application of urokinase for inner ear therapy
| Project/Area Number |
23791880
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KASHIO Akinori 東京大学, 医学部附属病院, 助教 (20451809)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ウロキナーゼ / アポトーシス / MAPK / 内耳有毛細胞 / らせん神経節細胞 / 内耳障害 / 有毛細胞 / らせん神経節 / Ｐ３８ / アミノ配糖体 / ＭＡＰＫ |
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| Research Abstract |
Urokinase is a drug used clinically as a thrombolytic agent. Recently, the anti-apoptotic effect of the urokinase has been reported. In this study, we have examined weather urokinase has the anti-apoptotic effect to the inner ear cells. We have shown that urokinase attenuated the inner ear hair cell death caused by aminoglicoside using the cochlear organotypic cultures. Expression of P38 could be seen in those who had given urokinase concomitantly with aminoglicoside, which suggested that urokinase showed antiapoptotic effect by activating the p38 MAPK pathway. We also showed that urokinase decreased the spiral ganglion cells death caused by gulutate. These result showed that urokinase could be one of a prommising drug for the inner ear therapy in future.
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Report
(4 results)
Research Products
(29 results)
