| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Research Abstract |
In the present study, we analyzed structural-functional interaction of a mammalian candidate sour taste receptor, PKD1L3/PKD2L1 complex. We aimed to identify the molecular determinants responsible for the Ca2+ permeability of the PKD1L3/PKD2L1 complex. By Ca2+ imaging analyses, we demonstrated that the single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex.
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