Role of Epithelial mesenchimal transition in tenporal bone squamous cell carcinoma

• Project/Area Number: 23791884
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: SUGIMOTO Hisashi 金沢大学, 医学系, 助教 (20547179)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 上皮間葉移行 / 側頭骨原発扁平上皮癌 / 側頭骨扁平上皮癌 / 扁平上皮癌 / RANK/RANKL / TGFβ

Research Abstract

This study showed correlations in EMT with extensive bone involvement. The results suggest that EMTtends to correlate with poor prognosis for SCC of the temporal bone, and that this correlation is an indirect relationship resulting from the promotion of bone invasion by EMT.

Research Products

• [Journal Article] Retrograde approach and soft wall reconstruction for surgery in congenital cholesteatoma (2013)
  • Author(s): Sugimoto H, Ito M, Yoshizaki T
  • Journal Title: Acta Otolaryngol Volume: 133(11) Pages: 1142-7
  • Peer Reviewed
• [Journal Article] Retrograde approach and soft wall reconstruction for surgery in congenital cholesteatoma. (2013)
  • Author(s): Hisashi Sugimoto
  • Journal Title: Acta Otolaryngol Volume: 133 Issue: 11 Pages: 1142-7
  • DOI: 10.3109/00016489.2013.817683
  • Peer Reviewed
• [Journal Article] Cochlear implantation in a patient with superficial siderosis (2012)
  • Author(s): Sugimoto H, Ito M, Yoshizaki T
  • Journal Title: Auris Nasus Larynx Volume: 39 Pages: 623-626
  • Peer Reviewed
• [Journal Article] Concurrent superselective intra-arterial chemotherapy and radiotherapy for late-stage squamous cell carcinoma (2011)
  • Author(s): Sugimoto H, Ito M, Shinya Yoshida, Hatano M, Yoshizaki T
  • Journal Title: Ann Otol Rhino Larygo Volume: 120 Pages: 372-376
  • Peer Reviewed
• [Journal Article] Roles of Epithelial-Mesenchymal Transition in squamous cell carcinoma of the temporal bone (2011)
  • Author(s): Sugimoto H
  • Journal Title: Otology&Neurotology Volume: 32 Pages: 483-487
  • NAID: 120002986040
  • Peer Reviewed
• [Journal Article] Concurrent superselective intra-arterial chemotherapy and radiotherapy for late-stage squamous (2011)
  • Author(s): Sugimoto H
  • Journal Title: Annals of Otology Rhinology & Laryngology Volume: 32 Pages: 372-376
  • Peer Reviewed
• [Presentation] アブミ骨動脈遺残の１例 (2014)
  • Author(s): 杉本寿史
  • Organizer: 第２４回頭頸部外科学会
  • Place of Presentation: 高松市 サンポート高松
• [Presentation] Retrograde approach and soft wall reconstruction for surgery of congenital cholesteatoma (2013)
  • Author(s): Hisashi Sugimoto, Makoto Ito, Tomokazu Yoshizaki
  • Organizer: 20th IFOS World Congress
  • Place of Presentation: Seoul, Korea
• [Presentation] Retrograde approach and soft wall reconstruction for surgery of congenital cholesteatoma. (2013)
  • Author(s): Hisashi Sugimoto
  • Organizer: 20th IFOS World Congress
  • Place of Presentation: Seoul, Korea
• [Presentation] 当科における先天性真珠腫の統計的観察 (2012)
  • Author(s): 杉本寿史、伊藤真人、吉崎智一
  • Organizer: 日本耳科学会
  • Place of Presentation: 名古屋市
• [Presentation] Pathology presenting features immunopathology : Panel discussion, Temporal bone malignancy (2012)
  • Author(s): Hisashi Sugimoto, Ito M, Yoshizaki T
  • Organizer: The 9^<th> international conference on cholesteatoma and ear surgery
  • Place of Presentation: Nagasaki
• [Presentation] 先天性中耳真珠腫の臨床的検討 (2012)
  • Author(s): 杉本寿史、伊藤真人、吉崎智一
  • Organizer: 第113回日本耳鼻咽喉科学会総会
  • Place of Presentation: 新潟市
• [Presentation] Pathology presenting features immunopathology (2012)
  • Author(s): Hisashi Sugimoto
  • Organizer: 第9回国際真珠腫学会
  • Place of Presentation: 長崎ブリックホール
• [Presentation] 当科における先天性真珠腫の統計的観察 (2012)
  • Author(s): 杉本寿史
  • Organizer: 第113回日本耳鼻咽喉科学会
  • Place of Presentation: 新潟 朱鷺メッセ
• [Presentation] 先天性真珠腫の臨床的検討 (2012)
  • Author(s): 杉本寿史
  • Organizer: 第22回日本耳科学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Cochlear implantation in a patient with superficial siderosis (2011)
  • Author(s): Hisashi Sugimoto, Makoto Ito, Tomokazu Yoshizaki
  • Organizer: 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Place of Presentation: ANA CROWN PLAZA KOBE
• [Presentation] Cochlear implantation in a patient with superficial siderosis (2011)
  • Author(s): Hisashi Sugimoto, Makoto Ito, Tomokazu Yoshizaki
  • Organizer: 28th Politzer Society Meeting
  • Place of Presentation: Athene, Greece
• [Presentation] 標準純音聴力検査の結果が良好であったAuditory neuropathyの1例 (2011)
  • Author(s): 杉本寿史、伊藤真人、吉崎智一
  • Organizer: 第73回耳鼻咽喉科臨床会
  • Place of Presentation: 松本市
• [Presentation] 進行期聴器扁平上皮癌に対し放射線併用超選択的動注化学療法を行った6症例の検討 (2011)
  • Author(s): 杉本寿史、伊藤真人、波多野都、吉崎智一
  • Organizer: 日本耳鼻咽喉科学会総会
  • Place of Presentation: 京都市
• [Presentation] 進行期聴器扁平上皮癌に対し放射線併用超選択的動注化学療法を行った５症例の検討
  • Author(s): 杉本 寿史
  • Organizer: 第112回日本耳鼻咽喉科学会総会
  • Place of Presentation: 京都府 国立京都国際会館
• [Presentation] 標準純音聴力検査の結果が良好であったAuditory neuropathyの１例
  • Author(s): 杉本 寿史
  • Organizer: 第73回耳鼻咽喉科臨床学会
  • Place of Presentation: 長野県 長野県松本文化会館
• [Presentation] Cochlear implantation in a patient with superficial siderosis
  • Author(s): 杉本 寿史
  • Organizer: 28th Politzer Society Meeting
  • Place of Presentation: ギリシャ The Westin Athens Astir Palace Beach Resort
• [Book] 上咽頭炎 (2011)
  • Author(s): 杉本寿史,伊藤真人
  • Publisher: 全日本病院出版会ENTONI
• [Book] 上咽頭炎 (2011)
  • Author(s): 杉本 寿史
  • Total Pages: 6
  • Publisher: ENTONI