| Project/Area Number |
23791888
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
NISHIO Shinya 信州大学, 医学部, 助教(特定雇用) (70467166)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 耳科学 / 内耳 / マイクロRNA / 遺伝子発現調節 / 老人性難聴 / 遺伝子発現 / DNAマイクロアレイ / 聴覚 |
|---|
| Research Abstract |
Micro RNA has important roll in many biological phenomena including development, differentiation, cancer etc. We examine the micro RNA and mRNA expression profiles of 12 weeks old and 20 weeks old senescence-accelerated model mouse (SAM-P1) cochlea and its control strain (SAM-R1) cochlea by using micro RNA microarray. The micro-RNA expression profiles in SAMP1 and SAMR1 mice were quite similar at 12 weeks. On the other hand, the expression profiles changed remarkably in 20 week old SAM-P1 mice than the other. Interestingly, miR-96, miR182 and miR183 which proposed as important factors for inner ear development and function were deceased about half in 20 weeks old SAM-P1, which revealed age related hearing loss.
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