Differential diagnosis of thyroid tumor by cleaved galectin-3
| Project/Area Number |
23791893
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 甲状腺癌 / 甲状腺 / ガレクチンー3 / マトリクスプロテアーゼ |
|---|
| Research Abstract |
We performed immunohistochemistry of surgical specimens of thyroid cancer with antibody against intact galectin-3 and antibody against cleaved galectin-3. Intact galectin-3 was diffusely expressed in any thyroid papillary cancer specimens. In contrast, galectin-3 expression in follicular cancer specimens varied depending on the specimens. Immunohistochemistry with anti-cleaved galectin-3 antibody have been unsuccessful so far, and we are now working on it. Also, we are working on the establishment of cleaved galectin-3 detection system with ELISA. With respect to clinical study, we are investigating the association between galectin-3 expression and prognosis of follicular cancer.
|
Report
(3 results)
Research Products
(1 results)
