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Differential diagnosis of thyroid tumor by cleaved galectin-3

Research Project

Project/Area Number 23791893
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionOsaka University

Principal Investigator

TAKENAKA Yukinori  大阪大学, 医学系研究科, 助教 (40598398)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords甲状腺癌 / 甲状腺 / ガレクチンー3 / マトリクスプロテアーゼ
Research Abstract

We performed immunohistochemistry of surgical specimens of thyroid cancer with antibody against intact galectin-3 and antibody against cleaved galectin-3. Intact galectin-3 was diffusely expressed in any thyroid papillary cancer specimens. In contrast, galectin-3 expression in follicular cancer specimens varied depending on the specimens. Immunohistochemistry with anti-cleaved galectin-3 antibody have been unsuccessful so far, and we are now working on it. Also, we are working on the establishment of cleaved galectin-3 detection system with ELISA. With respect to clinical study, we are investigating the association between galectin-3 expression and prognosis of follicular cancer.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2010

All Journal Article (1 results)

  • [Journal Article] リン酸化ガレクチン-3 の癌細胞における役割(総説)2010

    • Author(s)
      竹中 幸則(大阪大学 大学院医学系研究科耳鼻咽喉科頭頸部外科学), 猪原 秀典
    • Journal Title

      耳鼻咽喉科免疫アレルギー

      Volume: 28巻 4号 Pages: 273-277

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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