The modulation of 5-HT3 receptor responses by anticancer drug

• Project/Area Number: 23791895
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: NAKAMURA Yukiko 大阪大学, 医学(系)研究科(研究院), 助教 (90548083)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 頭頸部外科学 / セロトニン / 受容体 / セロトニン３受容体 / 抗癌剤 / 嘔吐

Research Abstract

It has been shown that anti-cancer drug induces secretion of serotonin (5-HT) from small intestine which activates serotonin type 3 (5-HT3) receptor to cause nausea and vomiting. In general, antagonist for 5-HT3 receptor is used as anti-emetics during chemotherapy. However, we found that anti-cancer drug irinotecanitself inhibits 5-HT -gated current through the homomeric 5-HT3 receptor in aconcentration-dependent manner. Our findings suggest that irinotecan itself could have anti-emetic activities through inhibition of the 5-HT3 receptor.

Research Products

• [Journal Article] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan (2013)
  • Author(s): Yukiko Nakamura, Yusuke Ishida, Takahiro Yamada, Kondo Makoto, Shoichi Shimada.
  • Journal Title: Journal of neurochemistry Volume: 125(1) Pages: 7-15
  • Peer Reviewed
• [Journal Article] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan” Journal of neurochemistry (2013)
  • Author(s): Yukiko Nakamura
  • Journal Title: Journal of neurochemistry Volume: 125(1) Issue: 1 Pages: 7-15
  • DOI: 10.1111/jnc.12146
  • Peer Reviewed
• [Journal Article] Anticancer drug irinotecan inhibits himomerid5-HT3A and heteromeric 5-HT3AB receptor responses (2011)
  • Author(s): Yukiko Nakamura, Yusuke Ishida, Takahiro Yamada, Shoichi Shimada
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 415(2) Pages: 416-20
  • Peer Reviewed
• [Journal Article] Anticancer drug irinotecan inhibits homomeric 5-HT3A and heteromeric 5-HT3AB receptor responses. (2011)
  • Author(s): Yukiko Nakamura
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 415(2) Issue: 2 Pages: 416-420
  • DOI: 10.1016/j.bbrc.2011.10.084
  • Peer Reviewed
• [Presentation] 抗癌剤トポテカンによるセロトニン 3 受容体のサブユニットに依存した応答調節 (2013)
  • Author(s): 中村 雪子
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松・かがわ国際会議場(香川)
  • Year and Date: 2013-03-29
• [Presentation] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan (2012)
  • Author(s): Yukiko Nakamura
  • Organizer: 第55回日本神経化学学会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2012-10-01
• [Presentation] 抗癌剤トポテカンによる5-HT3 受容体 Subunit-dependent な促進と阻害 (2012)
  • Author(s): 中村 雪子
  • Organizer: 第14回 ORIGIN 神経科学研究会
  • Place of Presentation: 北陸 粟津温泉 法師(金沢)
  • Year and Date: 2012-09-01
• [Presentation] 抗癌剤イリノテカンはセロトニン3A受容体およびセロトニン3AB受容体を抑制する (2012)
  • Author(s): 中村 雪子
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス山梨
  • Year and Date: 2012-03-27
• [Presentation] 抗癌剤イリノテカンはセロトニン３A受容体およびセロトニン３AB受容体を抑制する (2012)
  • Author(s): 中村 雪子
  • Organizer: 第117回 日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス（山梨）
• [Presentation] Anticancer drug irinotecan inhibits the response of 5-HT3A receptor (2011)
  • Author(s): Yukiko Nakamura
  • Organizer: 第54回日本神経化学学会
  • Place of Presentation: 山城温泉瑠璃光(石川)
  • Year and Date: 2011-09-26
• [Presentation] 抗癌剤イリノテカンはセロトニン3A受容体の応答を抑制する (2011)
  • Author(s): 中村 雪子
  • Organizer: 第13回ORIGIN 神経科学研究会
  • Place of Presentation: ホテル竹園芦屋(兵庫)
  • Year and Date: 2011-08-20
• [Presentation] 抗癌剤イリノテカンはセロトニン３A受容体の応答を抑制する (2011)
  • Author(s): 中村 雪子
  • Organizer: 第13回 ORIGIN 神経科学研究会
  • Place of Presentation: ホテル竹園芦屋（兵庫）
• [Presentation] Anticancer drug irinotecan inhibits the response of 5-HT3A receptor (2011)
  • Author(s): Yukiko Nakamura
  • Organizer: 第54回日本神経化学学会
  • Place of Presentation: 山代温泉瑠璃光（石川）
• [Presentation] 抗癌剤トポテカンによるセロトニン3受容体のサブユニットに依存した応答調節
  • Author(s): 中村 雪子
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松・かがわ国際会議場(香川）
• [Presentation] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan
  • Author(s): Yukiko Nakamura
  • Organizer: 第55回日本神経化学学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] 抗癌剤トポテカンによる5-HT3受容体Subunit-dependentな促進と阻害
  • Author(s): 中村 雪子
  • Organizer: 第14回 ORIGIN神経科学研究会
  • Place of Presentation: 北陸 粟津温泉 法師（金沢）