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The modulation of 5-HT3 receptor responses by anticancer drug

Research Project

Project/Area Number 23791895
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionOsaka University

Principal Investigator

NAKAMURA Yukiko  大阪大学, 医学(系)研究科(研究院), 助教 (90548083)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords頭頸部外科学 / セロトニン / 受容体 / セロトニン3受容体 / 抗癌剤 / 嘔吐
Research Abstract

It has been shown that anti-cancer drug induces secretion of serotonin (5-HT) from small intestine which activates serotonin type 3 (5-HT3) receptor to cause nausea and vomiting. In general, antagonist for 5-HT3 receptor is used as anti-emetics during chemotherapy. However, we found that anti-cancer drug irinotecanitself inhibits 5-HT -gated current through the homomeric 5-HT3 receptor in aconcentration-dependent manner. Our findings suggest that irinotecan itself could have anti-emetic activities through inhibition of the 5-HT3 receptor.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (12 results)

  • [Journal Article] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan2013

    • Author(s)
      Yukiko Nakamura, Yusuke Ishida, Takahiro Yamada, Kondo Makoto, Shoichi Shimada.
    • Journal Title

      Journal of neurochemistry

      Volume: 125(1) Pages: 7-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan” Journal of neurochemistry2013

    • Author(s)
      Yukiko Nakamura
    • Journal Title

      Journal of neurochemistry

      Volume: 125(1) Issue: 1 Pages: 7-15

    • DOI

      10.1111/jnc.12146

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer drug irinotecan inhibits himomerid5-HT3A and heteromeric 5-HT3AB receptor responses2011

    • Author(s)
      Yukiko Nakamura, Yusuke Ishida, Takahiro Yamada, Shoichi Shimada
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 415(2) Pages: 416-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer drug irinotecan inhibits homomeric 5-HT3A and heteromeric 5-HT3AB receptor responses.2011

    • Author(s)
      Yukiko Nakamura
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 415(2) Issue: 2 Pages: 416-420

    • DOI

      10.1016/j.bbrc.2011.10.084

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗癌剤トポテカンによるセロトニン 3 受容体のサブユニットに依存した応答調節2013

    • Author(s)
      中村 雪子
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場(香川)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan2012

    • Author(s)
      Yukiko Nakamura
    • Organizer
      第55回日本神経化学学会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2012-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗癌剤トポテカンによる5-HT3 受容体 Subunit-dependent な促進と阻害2012

    • Author(s)
      中村 雪子
    • Organizer
      第14回 ORIGIN 神経科学研究会
    • Place of Presentation
      北陸 粟津温泉 法師(金沢)
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗癌剤イリノテカンはセロトニン3A受容体およびセロトニン3AB受容体を抑制する2012

    • Author(s)
      中村 雪子
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス山梨
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗癌剤イリノテカンはセロトニン3A受容体およびセロトニン3AB受容体を抑制する2012

    • Author(s)
      中村 雪子
    • Organizer
      第117回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨)
    • Related Report
      2011 Research-status Report
  • [Presentation] Anticancer drug irinotecan inhibits the response of 5-HT3A receptor2011

    • Author(s)
      Yukiko Nakamura
    • Organizer
      第54回日本神経化学学会
    • Place of Presentation
      山城温泉瑠璃光(石川)
    • Year and Date
      2011-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗癌剤イリノテカンはセロトニン3A受容体の応答を抑制する2011

    • Author(s)
      中村 雪子
    • Organizer
      第13回ORIGIN 神経科学研究会
    • Place of Presentation
      ホテル竹園芦屋(兵庫)
    • Year and Date
      2011-08-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗癌剤イリノテカンはセロトニン3A受容体の応答を抑制する2011

    • Author(s)
      中村 雪子
    • Organizer
      第13回 ORIGIN 神経科学研究会
    • Place of Presentation
      ホテル竹園芦屋(兵庫)
    • Related Report
      2011 Research-status Report
  • [Presentation] Anticancer drug irinotecan inhibits the response of 5-HT3A receptor2011

    • Author(s)
      Yukiko Nakamura
    • Organizer
      第54回日本神経化学学会
    • Place of Presentation
      山代温泉瑠璃光(石川)
    • Related Report
      2011 Research-status Report
  • [Presentation] 抗癌剤トポテカンによるセロトニン3受容体のサブユニットに依存した応答調節

    • Author(s)
      中村 雪子
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場(香川)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan

    • Author(s)
      Yukiko Nakamura
    • Organizer
      第55回日本神経化学学会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗癌剤トポテカンによる5-HT3受容体Subunit-dependentな促進と阻害

    • Author(s)
      中村 雪子
    • Organizer
      第14回 ORIGIN神経科学研究会
    • Place of Presentation
      北陸 粟津温泉 法師(金沢)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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