| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We aimed to investigate the pathophysiology of diabetes- associated hearing impairment in type1 diabetes using mice with diabetes. Chronologic changes in the ABR threshold shift were not significantly different between the diabetic and control groups. However, vessel walls in the modiolus of the cochleae were significantly thicker inthe diabetic group than the control group. Additionally, recovery from noise-induced injury was significantly impaired in diabetic mice. Our data suggest that diabetic cochleae are more susceptible than controls to loud noise exposure.
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