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Pathologic Elucidation of Olfactory Disorder Using Mass Spectrometry

Research Project

Project/Area Number 23791897
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKobe University

Principal Investigator

DOI Kiyoshi  神戸大学, 大学院・医学研究科, 助教 (00379380)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords嗅覚障害 / マイクロアレイ・BDNF / 嗅覚 / 遺伝子 / マイクロアレイ / メタボローム
Research Abstract

The olfactory receptor neurons have an unusual characteristic of continuous neurogenesis throughout its lifetime. We observed a dynamic state of gene in the regeneration process of olfactory receptor neurons. From this observation, it was suggested that BDNF, that is known as a neurotrophic factor participates to the olfactory regeneration process at early phase in the olfactory epithelium and at late phase in the olfactory bulb.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] BDNF expression in olfactory bulb and epithelium during regeneration of olfactory epithelium2012

    • Author(s)
      Uranagase A, Katsunuma S, Doi K, Nibu K
    • Journal Title

      Neurosci Lett

      Volume: 516 Pages: 45-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Evaluation of card-type odor identification test for Japanese patients with olfactory disturbance2012

    • Author(s)
      Fujio H, Doi K, Hasegawa S, Kobayakawa T,Nibu K
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 121 Pages: 413-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Evaluation of card-type odor identification test for Japanese patients with olfactory disturbance2012

    • Author(s)
      Fujio H
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 121(6) Pages: 413-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BDNF expression in the olfactory bulb and epithelium during regeneration of olfactoryt epithelium2012

    • Author(s)
      Uranagase A
    • Journal Title

      Neuroscience Letter

      Volume: 16(1) Pages: 45-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BDNF expression in olfactory bulb and epithelium during regeneration of olfactory epitheliium2012

    • Author(s)
      Uranagase A, Katsunuma S, Doi K, Nibu K
    • Journal Title

      Neuroscience Letters

      Volume: 516 Pages: 45-49

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Near-infrared spectroscopy of orbitofrontal cortex during odorant stimulation2011

    • Author(s)
      Kokan N, Sakai N, Doi K, Fujio H, Hasegawa S, Tanimoto H, Nibu K
    • Journal Title

      American Journal of Rhinology and Allerygy

      Volume: 25 Issue: 3 Pages: 163-165

    • DOI

      10.2500/ajra.2011.25.3634

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Urangase A, Nibu K, Doi K, Katsunuma S: DNF expression in olfactory bulb and epithelium during regeneration of olfactory epithelium.2011

    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology -Head and Neck Surgery
    • Place of Presentation
      Kobe
    • Year and Date
      2011-12-09
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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