The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice

• Project/Area Number: 23791899
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Shimane University
• Principal Investigator: FUCHIWAKI Takafumi 島根大学, 医学部, 助教 (10437543)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: CD30 ligand / allergic rhinitis / Th2 cells / CD30 Ig fusion protein / アレルギー性鼻炎 / CD30免疫グロブリン融合蛋白

Research Abstract

CD30L/CD30 signaling is more important in the secondary response at the allergic inflammatory site rather than during the initial phase of antigen priming in the LNs and spleen. The suppression of CD30L/CD30 signaling by soluble CD30-Ig fusion protein can suppress or regulate rhinitis development and might be useful for the therapy of allergic rhinitis.

Research Products

• [Journal Article] The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice (2011)
  • Author(s): Fuchiwaki T, Sun X, Fujimura K, Yamada H, Shibata K, Muta H, Podack ER, Kawauchi H, Yoshikai Y
  • Journal Title: Eur J Immunol Pages: 2947-54
  • Peer Reviewed
• [Presentation] アレルギー性鼻炎におけるCD30 ligand の役割 (2012)
  • Author(s): 淵脇貴史
  • Organizer: 第113回日本耳鼻咽喉科学会
  • Place of Presentation: (新潟),新潟コンベンションセンター
  • Year and Date: 2012-05-11
• [Presentation] アレルギー性鼻炎におけるCD30 ligand の役割 (2012)
  • Author(s): 淵脇貴史
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: (滋賀),琵琶湖ホテル
  • Year and Date: 2012-02-17
• [Presentation] The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice (2011)
  • Author(s): 淵脇貴史
  • Organizer: 30thInternational Symposium on Infection and Allergy of the Nose
  • Place of Presentation: (東京), ANA Intercontinental Tokyo
  • Year and Date: 2011-09-20
• [Presentation] The Central Role of CD30L/CD30 Interactions in Allergic Rhinitis Pathogenesis in Mice. (2011)
  • Author(s): 淵脇貴史
  • Organizer: IRS＆ISIAN 2011
  • Place of Presentation: ANA InterContinental Tokyo（東京都）