the pathophysiology of the inflammation in the eosinophilic otitis media

• Project/Area Number: 23791900
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Okayama University
• Principal Investigator: EGUCHI Motoharu 岡山大学, 大学病院, 助教 (30432652)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: サイトカイン / 好酸球 / 中耳炎 / 国際情報交換

Research Abstract

The middle ear effusion was collected from the patients with eosinophilic otitis media. The inflammatory factors in middle ear effusion were examined by cytokine array. Multiple inflammatory factors were observed in middle ear effusion in patients with eosinophilic otitis media. The animal study was carried out in BALB/c mice by immunization with ovalbumin mixed with aluminum hydroxide. The mice showed a accumulation of eosinophils in middle ear mucosa, and had many inflammatory factors in middle ear cavity. The mice showed similar pathophysiology as humans with eosinophilic otitis media.

Research Products

• [Journal Article] Neutralizing antibody against granulocyte/macrophage colony-stimulating factor inhibits inflammatory response in experimental otitis media. (2013)
  • Author(s): Kariya S, Okano M, Higaki T, Makihara S, Haruna T, Eguchi M, Nishizaki K.
  • Journal Title: Laryngoscope Volume: 123 Issue: 6 Pages: 1514-1518
  • DOI: 10.1002/lary.23795
  • Peer Reviewed
• [Journal Article] 鼻出血を契機に発見された鼻腔原発のglomangiopericytomaの1例 (2013)
  • Author(s): 大道亮太郎、假谷伸、岡野光博、牧原靖一郎、小野田友男、江口元治、西﨑和則
  • Journal Title: 頭頸部外科 Volume: vol.23 Pages: 141-144
  • NAID: 130003385963
  • Peer Reviewed
• [Journal Article] 当科における上咽頭癌症例の検討 (2013)
  • Author(s): 牧野琢丸、小野田友男、小山貴久、春名威範、江口元治、假谷伸、西﨑和則
  • Journal Title: 口腔咽頭科 Volume: vol.26 Pages: 203-206
  • NAID: 10031183790
  • Peer Reviewed
• [Journal Article] 舌癌に対する頸部郭清の適応に関する検討 (2011)
  • Author(s): 河野達也、小野田友男、江口元治、牧野琢丸、阿部郁、假谷伸、西﨑和則
  • Journal Title: 口腔・咽頭科 Volume: vol.24 Pages: 179-182
  • NAID: 10029059010
  • Peer Reviewed
• [Journal Article] Fanconi貧血に合併した舌癌の1例 (2011)
  • Author(s): 阿部郁、小野田友男、牧野琢丸、河野達也、江口元治、假谷伸、西﨑和則
  • Journal Title: 口腔・咽頭科 Volume: vol.24 Pages: 183-186
  • NAID: 10029059019
  • Peer Reviewed
• [Journal Article] Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D(2) receptor (DP)-dependent pathway (2011)
  • Author(s): Motoharu Eguchi, Shin Kariya, 他
  • Journal Title: Clinical and Experimental Immunology Volume: 163 Issue: 2 Pages: 260-269
  • DOI: 10.1111/j.1365-2249.2010.04292.x
  • Peer Reviewed
• [Presentation] Lipopolysaccharide-induced middle ear inflammation is inhibited by neutralization of endogenous granulocyte/macrophage colony-stimulating factor (GM-CSF) (2011)
  • Author(s): Shin Kariya, Mitsuhiro Okano, Takaya Higaki, Motoharu Eguchi, Yohei Noda, Kazunori Nishizaki
  • Organizer: The 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Place of Presentation: Kobe, Japan
• [Presentation] Role of prostaglandin D2 receptor in otitis media (2011)
  • Author(s): Shin Kariya, Motoharu Eguchi, Mitsuhiro Okano, Seiichiro Makihara, Takaya Higaki, Norimasa Morita, Kazunori Nishizaki
  • Organizer: The 115th AAO-HNSF Annual Meeting & OTO EXPO
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Expression of prostaglandin D2, macrophage inflammatory protein 2 (MIP-2), interleukin (IL)-1beta and IL-6 in lipopolysaccharide-induced otitis media in mice (2011)
  • Author(s): Hisashi Ishihara, Shin Kariya, Motoharu Eguchi, Mitsuhiro Okano, Seiichiro Makihara, Takaya Higaki, Kazunori Nishizaki
  • Organizer: The 1st Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
  • Place of Presentation: Barcelona, Spain
• [Presentation] Effect of prostaglandin D2 on the expression of macrophage inflammatory protein 2, interleukin-1 beta, and interleukin-6 by polymorphonuclear leukocytes in mice (2011)
  • Author(s): Shin Kariya, Motoharu Eguchi, Mitsuhiro Okano, Seiichiro Makihara, Takaya Higaki, Kazunori Nishizaki
  • Organizer: The 1st Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
  • Place of Presentation: Barcelona, Spain
• [Presentation] Expression of prostaglandin D2, macrophage inflammatory protein 2 (MIP-2), interleukin (IL)-1beta and IL-6 in lipopolysaccharide-induced otitis media in mice (2011)
  • Author(s): Hisashi Ishihara, Shin Kariya, Motoharu Eguchi, Mitsuhiro Okano, Seiichiro Makihara, Takaya Higaki, Kazunori Nishizaki
  • Organizer: The 1st Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
  • Place of Presentation: Barcelona, Spain
• [Presentation] Effect of prostaglandin D2 on the expression of macrophage inflammatory protein 2, interleukin-1 beta, and interleukin-6 by polymorphonuclear leukocytes in mice (2011)
  • Author(s): Shin Kariya, Motoharu Eguchi, Mitsuhiro Okano, Seiichiro Makihara, Takaya Higaki, Kazunori Nishizaki
  • Organizer: The 1st Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
  • Place of Presentation: Barcelona, Spain
• [Presentation] Lipopolysaccharide-induced middle ear inflammation is inhibited by neutralization of endogenous granulocyte/macrophage colony-stimulating factor (GM-CSF) (2011)
  • Author(s): Shin Kariya, Mitsuhiro Okano, Takaya Higaki, Motoharu Eguchi, Yohei Noda, Kazunori Nishizaki
  • Organizer: The 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery(招待講演)
  • Place of Presentation: Kobe, Japan