the pathophysiology of the inflammation in the eosinophilic otitis media
Project/Area Number |
23791900
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
|
Research Institution | Okayama University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | サイトカイン / 好酸球 / 中耳炎 / 国際情報交換 |
Research Abstract |
The middle ear effusion was collected from the patients with eosinophilic otitis media. The inflammatory factors in middle ear effusion were examined by cytokine array. Multiple inflammatory factors were observed in middle ear effusion in patients with eosinophilic otitis media. The animal study was carried out in BALB/c mice by immunization with ovalbumin mixed with aluminum hydroxide. The mice showed a accumulation of eosinophils in middle ear mucosa, and had many inflammatory factors in middle ear cavity. The mice showed similar pathophysiology as humans with eosinophilic otitis media.
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Report
(4 results)
Research Products
(13 results)