| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
In our previous study, we have indicated that keratinocyte growth factor (KGF) plays an important role in middle ear cholesteatoma formation. KGF is a mesenchymal-cell-derived paracrine growth factor that specifically stimulates epithelial cell growth. In this study, we investigated the effects of over-expressed KGF in vivo. As results, a single injection of KGF expression vector coupled with electroporation induced inflammatory reaction and increased proliferative activity of epithelial cells in external auditory canal, and consequently KGF may possibly induce a cholesteatoma formation. Treatment of rats of the long-term model with SU5402, a KGFreceptor inhibitor, prevented cholesteatoma formation.
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