Functional analysis and differentiation induction of antigen presenting cells via DDS in human nasal epithelial cells

• Project/Area Number: 23791915
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Sapporo Medical University
• Principal Investigator: GO Mitsuru 札幌医科大学, 医学部, 講師 (80448604)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 咽頭科学 / 鼻アレルギー / タイト結合 / 鼻粘膜 / M細胞

Research Abstract

Nasopharynx and nasal mucosa are located at the forefront of the host defense against foreign pathogens, which plays an important role in acquired immunityand innate immunity. To elucidate the immune system of allergy infection, we analyzed the mechanism of epithelial barrier function and antigen presentation in the nasalepithelium of human nasopharyngeal epithelium.

Research Products

• [Journal Article] Regulation of tight junctions in upper airway epithelium. (2013)
  • Author(s): Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, Kamekura R, Ogasawara N, Masaki T, Fuchimoto J, Obata K, Hirakawa S, Nomura K, Keira T, Miyata R, Fujii N, Tsutsumi H, Himi T, Sawada N.
  • Journal Title: Biomed Res Int
  • Peer Reviewed
• [Journal Article] The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. (2012)
  • Author(s): Kamekura R, Kojima T, Takano K, Go M, Sawada N, Himi T.
  • Journal Title: Clin Exp Allergy Volume: 42 Pages: 218-228
  • Peer Reviewed
• [Journal Article] Mucosal immune barrier and antigen-presenting system in human nasal epithelial cells (2011)
  • Author(s): Himi T, Takano K, Ogasawara N, Go M, Kurose M, Koizumi J, Kamekura R, Kondo A, Ohkuni T, Masaki T, Kojima T, Sawada N, Tsutsumi H
  • Journal Title: Adv Otorhinolaryngol. Volume: 72 Pages: 28-30
  • Peer Reviewed