| Project/Area Number |
23791916
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Research Collaborator |
HIMI Tetsuo 札幌医科大学, 医学部, 教授 (90181114)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 鼻粘膜 / ウイルス / 受容体 / 上気道 / 生体防御 / 上皮 / 自然免疫 / タイト結合 / RSウイルス |
|---|
| Research Abstract |
The airway epithelium is the first line of biological defense during respiratory viral infection. In the present study, we made analysis of innate immune system against early phase viral infection in experiments on human nasal epithelial cells (HNECs) infected with RS virus. In our experiments, these results indicated that 1) RIG-I may play the major role in the recognition of RS virus, 2) RS virus infection induces the secretion of type III interferon, 3) RS virus infection changes the localization of tight junction proteins, claudin4 and occludin.
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