Study of phase variation and intractable acute otitis media at the time of mixed infection of Streptococcus pneumoniae and Haemophilus influenzae
Project/Area Number |
23791926
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Wakayama Medical University |
Principal Investigator |
UENO Yumi 和歌山県立医科大学, 医学部, 博士研究員 (10445091)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 急性中耳炎 / 肺炎球菌 / インフルエンザ菌 / フェーズ変化 / 耐性化 |
Research Abstract |
Pneumococcal phase variation of 37 middle ear and 31 nasopharyngeal isolates obtained from children with acute otitis media was examined in the absence of intervening culture. The fraction of the opaque colonies was significantly higher in middle ear isolates than in nasopharyngeal isolates. We observed the identical PFGE pattern on the strains showing different phase variation pattern in the middle ear fluid and in the nasopharynx.The difference is probably the result of the pneumococci adapting to differential selective environments.
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Report
(3 results)
Research Products
(3 results)