Artificial Synapse Formation for the Implantable Artificial Organ of Corti
| Project/Area Number |
23791930
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | らせん神経節 / 内耳 / 蝸牛 / シナプス / 神経成長因子 / 聴力 / 蝸牛恒常性 / らせん神経節細胞 / 瘢痕 / 人工シナプス / 感音難聴 / 治療 / コーティング |
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| Outline of Final Research Achievements |
The aim of the present study is to form synapses between the spiral ganglion (SG) neurons and beads. I got following results. 1. SG neurons formed more neuronal fiber adhesion to beads coated with neurotrophic factor than to those without any chemicals. 2. Neurite outgrowth was impeded by cells around the organ of Corti. 3. A reliable evidence of synaptic marker expression was not obtained at beads contacted with neurites. 4. Cochlear homeostasis is critical for regeneration of cochlear cells. 5. Taken together, I again realized that prevention of hearing loss and revealing the mechanism of hearing loss are important in addition to treatments, because achieving a complete recovery of sensorineural hearing loss seems to be very hard.
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Report
(5 results)
Research Products
(5 results)
