| Project/Area Number |
23791943
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
WADA Kota 東京慈恵会医科大学, 医学部, 講師 (20307482)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 副鼻腔 / 好酸球 / 副鼻腔炎 / 好酸球性副鼻腔炎 / IL-33 / Alternaria / 上皮細胞 / 線維芽細胞 / ＩＬ－３３ / 慢性副鼻腔炎 / 気管支喘息 / アスピリン喘息 / 喘息 / ウィルス感染 |
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| Outline of Final Research Achievements |
We performed hematoxylin and eosin stain using the tissue which we obtained and observed degree of the eosinophil leukocytic infiltrate, an epithelial cells and performed immunostaining for IL -33. It showed eosinophil infiltrate in the atopic type bronchial asthma patients, the non-atopic type bronchial asthma patients, the patients with aspirin asthma strongly. The staining of IL -33 tended to be stained by epithelium. We tended to be stained in patients with eosinophilic rhinosinusitis, but the significant difference was absent. We cultured fibroblasts from a nasal polyp, and Alternaria stimulation showed the production of IL-6. However, the production of IL -33 from fibroblasts was absent. We cultured epithelial cells derived from nose and sinus mucosa and we established culture system, but were not able to do it about the state of the production of IL -33, the genetic expression.
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