Chemokine receptor and cancer stem cell markers in head and neck carcinoma

• Project/Area Number: 23791946
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Hyogo Medical University
• Principal Investigator: UWA nobuhiro 兵庫医科大学, 医学部, 講師 (90412048)
• Research Collaborator: TSUJIMURA Tohru 兵庫医科大学, 医学部, 教授 (20227408) ; SAGAWA Kousuke 兵庫医科大学, 医学部, 助教 (40441307) ; TERADA Tomonori 兵庫医科大学, 医学部, 講師 (00340977)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 上咽頭癌 / CD44 / 予後因子 / 放射線化学療法 / 頭頸部癌 / 癌幹細胞 / 免疫染色 / ケモカインレセプター

Research Abstract

The oncogenic mechanism of CD44 and the clinical/prognostic significance of CD44 expression in nasopharyngeal carcinoma (NPC) still remain to be clarified. This study aimed to demonstrate the significance of CD44 expression as a prognostic factor in NPC. A total of 42 patients were examined who received concurrent chemo-radiotherapy as the initial treatment. We evaluated the expressions of CD44 variant isoforms CD44v3, CD44v4, CD44v5, CD44v6, and CD44v7 in NPC patients, followed by their association with CCRT failure and the disease specific survival. The disease-specific survival rate was significantly poorer in patients with a high expression of CD44v3. The patients with a high expression of CD44v6 particularly showed a clinically incomplete response to CCRT at the primary site. A thorough analysis of CD44v3 and CD44v6 expression in NPC may be markedly beneficial for the determination of effective treatment strategies.

Research Products

• [Presentation] CD44 expression in biopsy specimens of patients with nasopharyngeal carcinoma is associated with prognosis (2013)
  • Author(s): Sagawa,K.,Uwa,N.,Terada,T.,Kida,K. and Sakagami,M.
  • Organizer: 117^<th> American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting
  • Place of Presentation: Vancouver、Canada
• [Presentation] 当科における上咽頭癌の治療成績および免疫染色を用いた予後因子の検討 (2013)
  • Author(s): 佐川公介、宇和伸浩、寺田友紀、貴田紘太、阪上雅史
  • Organizer: 第23回日本頭頸部外科学会
  • Place of Presentation: 鹿児島
• [Presentation] CD44 expression in biopsy specimens of patients with nasopharyngeal carcinoma is associated with prognosis (2013)
  • Author(s): Sagawa, K., Uwa, N., Terada, T., Kida,K., and Sakagami, M
  • Organizer: 117th American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] 当科における上咽頭癌の治療成績および免疫染色を用いた予後因子の検討 (2013)
  • Author(s): 佐川公介、宇和伸浩、寺田友紀、貴田紘太、阪上雅史
  • Organizer: 第23日本頭頸部外科学会
  • Place of Presentation: 鹿児島
• [Presentation] 当科における上咽頭癌症例の検討 (2012)
  • Author(s): 佐川公介、宇和伸浩、寺田友紀、阪上雅史
  • Organizer: 第36回日本頭頸部癌学会
  • Place of Presentation: 島根