Molecular pathological analysis of presbycusis ~focused on cochlear lateral wall~
| Project/Area Number |
23791953
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Showa University (2015)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2011-2014) |
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Principal Investigator |
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| Research Collaborator |
KITAMURA KEN 東京医科歯科大学, 大学院耳鼻咽喉科, 特任教授
IKEZONO TETSURO 埼玉医科大学, 耳鼻咽喉科, 教授
SHIGEMOTO KAZUHIRO 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 部長
SAWABE MOTOJI 東京医科歯科大学, 医学部・保健衛生学科, 教授
KUBO SACHIHO 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 前研究員
KOBAYASHI HITOME 昭和大学, 医学部・耳鼻咽喉科学講座, 教授
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ヒト側頭骨病理 / 老人性難聴 / レーザーマイクロダイゼクション / ラセン靱帯 / cochlin / レーザーマイクロダイゼクション法 / ヒト側頭骨病理学 / MELAS / 血管条 / 蝸牛外側壁 / mRNA / 免疫染色 / ミトコンドリアDNA |
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| Outline of Final Research Achievements |
1. Introduction of Laser microdissection for the analysis of human temporal bone pathology: We succeeded in the detection of mRNA expression of COCH in spiral ligaments and SLC26A5 in outer hair cells. 2. Presbycusis and cochlin : Distribution of cochlin imunostaining is changed with aging. 3. Influence of mitochondria DNA mutation in the cochlear lateral wall: in the case of mt3243 point mutation, the ratio of mtDNA 3243 mutation was low but atrophy of stria vascular was severe. Because stria vascularis requires high energy and mitochondrial rich organ, it is weak to the mutation even at low level.
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Report
(6 results)
Research Products
(29 results)
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[Journal Article] 神経疾患に伴う声帯運動障害2012
Author(s)
木村百合香
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Journal Title
Nippon Jibiinkoka Gakkai Kaiho
Volume: 115
Issue: 11
Pages: 992-993
DOI
NAID
ISSN
0030-6622, 1883-0854
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[Presentation] Mitochondrial DNA Haplogroup Analysis Associated with Presbycusis in a Japanese Population.2012
Author(s)
Kato T, Fuku N, Noguchi Y, Murakami H, Miyachi M, Kimura Y, Tanaka M, Kitamura K.
Organizer
The 1st Asian Otology Meeting and the 3rd East Asian Symposium on Otology,
Place of Presentation
Nagasaki Brick Hall, Nagasaki, Japan
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