The development of a new therapy for diabetic retinopathy targeting the receptor-associated prorenin system
| Project/Area Number |
23791955
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 受容体随伴プロレニン系 / 糖尿病網膜症 / プロレニン / （プロ）レニン受容体 / 網膜虚血再灌流 / 酸化ストレス / 虚血網膜 |
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| Research Abstract |
The present study for the first time demonstrated that reactive oxygen species derived from ischemia-reperfusion injury didn't activate the receptor-associated prorenin system in the retina. Moreover, the statistical analysis using the data form the patients with or without diabetes clearly demonstrated that the higher HbA1c and blood pressure were largely associated with the prorenin concentration in the blood. A further experiment is still being carried out using extracted porcine retinal arteriole in order to determine the role of prorenin in the regulation of retinal circulation.
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Report
(3 results)
Research Products
(7 results)
