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The development of a new therapy for diabetic retinopathy targeting the receptor-associated prorenin system

Research Project

Project/Area Number 23791955
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionAsahikawa Medical College

Principal Investigator

YOKOTA Harumasa  旭川医科大学, 医学部, 助教 (60431417)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords受容体随伴プロレニン系 / 糖尿病網膜症 / プロレニン / (プロ)レニン受容体 / 網膜虚血再灌流 / 酸化ストレス / 虚血網膜
Research Abstract

The present study for the first time demonstrated that reactive oxygen species derived from ischemia-reperfusion injury didn't activate the receptor-associated prorenin system in the retina. Moreover, the statistical analysis using the data form the patients with or without diabetes clearly demonstrated that the higher HbA1c and blood pressure were largely associated with the prorenin concentration in the blood. A further experiment is still being carried out using extracted porcine retinal arteriole in order to determine the role of prorenin in the regulation of retinal circulation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2013 Other

All Presentation (7 results)

  • [Presentation] 分散ヘスペレチンは虚血性網膜症の神経節細胞死を抑制する2013

    • Author(s)
      下内 明人 横田 陽匡
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Water-dispersible hesperetin prevents ganglion cell loss in the retina after retinal ischemia reperfusion injury.2013

    • Author(s)
      Akito Shimouch, Harumasa Yokota
    • Organizer
      2013 The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非糖尿病患者における血中プロレニン値に関係する因子

    • Related Report
      2012 Final Research Report
  • [Presentation] The serum levels of prorenin in Non-Diabetic Subjects

    • Related Report
      2012 Final Research Report
  • [Presentation] 分散ヘスペレチンは虚血性網膜症の神経節細胞死を抑制する

    • Related Report
      2012 Final Research Report
  • [Presentation] Water-dispersible hespertin prevents ganglion cell loss in the retinal ischemia reperfusion injury

    • Related Report
      2012 Final Research Report
  • [Presentation] 非糖尿病患者における血中プロレニン値に関する因子

    • Author(s)
      横田陽匡
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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