| Project/Area Number |
23791960
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Iwate University (2012)
Tohoku University (2011) |
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Principal Investigator |
SUGANO Eriko 岩手大学, 工学部, 特任准教授 (70375210)
|
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 視覚誘発電位 / 遺伝子導入 / プロモーター / 網膜色素変性症 / 視細胞変性 / 視細胞 / アデノ随伴ウイルス / 遺伝子治療 |
|---|
| Research Abstract |
In this study, appropriate vectors for Replacement Therapy" were investigated. To express a target gene to photoreceptors, rhodopsin promoter was tested. But the target gene expression induced by the promoter was extremely low. The regulator element of IRBP in conjunction with PDE promoter improve the expression, which was restricted to photoreceptors. But the region of the trans-gene expressed cells was limited to the injected area.
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