Strategy of the therapy for proliferative vitreoretinopathy andfunctional analysis of the hyalocytes

• Project/Area Number: 23791963
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Yamagata University
• Principal Investigator: NISHITSUKA Koichi 山形大学, 医学部, 助教 (60422169)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 硝子体細胞 / 眼内増殖性疾患 / ヒアルロナン / 増殖糖尿病網膜症 / 増殖硝子体網膜症 / 増殖性硝子体網膜症 / 硝子体生検 / IL-1 alpha / アポトーシス / IL-1 beta

Research Abstract

Inflammatoly cytokines increased in intraocular proliferativediseases induced the hyaluronan production regulation on porcine vitreous derived cellswhich we have established. To compare this cell reaction, we established theconjunctiva-derived cell strains. Inflammatoly cytokines also induced the hyaluronanproduction on these cell strains.

Research Products

• [Journal Article] 手術時期の異なる増殖糖尿病網膜症に対する硝子体手術成績の検討 (2012)
  • Author(s): 西勝弘, 後藤早紀子, 西塚弘一, 望月典子, 武田祐介, 阿部さち, 山本禎子, 山下英俊
  • Journal Title: 臨床眼科 Volume: 67巻 Pages: 69-75
  • Peer Reviewed
• [Journal Article] 【網膜硝子体疾患診療の進歩2012】治療手技の進歩硝子体手術の進歩内視鏡を用いた硝子体手術 (2012)
  • Author(s): 西塚弘一
  • Journal Title: あたらしい眼科 Volume: 29巻 Pages: 204-208
• [Journal Article] 【網膜硝子体疾患診療の進歩2012】 治療手技の進歩 硝子体手術の進歩 内視鏡を用いた硝子体手術 (2012)
  • Author(s): 西塚 弘一
  • Journal Title: あたらしい眼科 Volume: 29 Pages: 204-208
• [Journal Article] Funagata Study.Determinants and risk factors forcentral corneal thickness in Japanesepersons: the Funagata Study (2011)
  • Author(s): Nishitsuka K, Kawasaki R, Kanno M,Tanabe Y, Saito K, Honma K, Oizumi T,Daimon M, Kato T, Kayama T,Yamashita H
  • Journal Title: Ophthalmic Epidemiol Volume: 18(5) Pages: 244-9
  • Peer Reviewed
• [Journal Article] Hyaluronan production andhyaluronan synthase expression inthree human conjunctiva-derived cellstrains (2011)
  • Author(s): Kashiwagi Y, Nishitsuka K, YamamotoT, Takamura H, Yamashita H
  • Journal Title: Jpn J Ophthalmol Volume: 55(6) Pages: 660-9
  • Peer Reviewed
• [Journal Article] Determinants and risk factors for central corneal thickness in Japanese persons: the Funagata Study. (2011)
  • Author(s): Nishitsuka K, Kawasaki R, Kanno M, Tanabe Y, Saito K, Honma K, Oizumi T, Daimon M, Kato T, Kayama T, Yamashita H
  • Journal Title: Ophthalmic Epidemiology Volume: 18 Issue: 5 Pages: 244-249
  • DOI: 10.3109/09286586.2011.594206
  • Peer Reviewed
• [Journal Article] Hyaluronan production and hyaluronan synthase expression in three human conjunctiva-derived cell strains. (2011)
  • Author(s): Kashiwagi Y, Nishitsuka K, Yamamoto T, Takamura H, Yamashita H.
  • Journal Title: Jpn J Ophthalmol. Volume: 55 Issue: 6 Pages: 660-669
  • DOI: 10.1007/s10384-011-0072-9
  • NAID: 10030248067
  • Peer Reviewed
• [Presentation] Efficacy ofophthalmic endoscope for vitrectomy incases with corneal opacity (2012)
  • Author(s): Nishitsuka K, Yamashita H
  • Organizer: 108th Annual Meeting of The Korean Ophthalmological Society
  • Place of Presentation: KINTEX, ソウル(韓国)
  • Year and Date: 2012-11-11
• [Presentation] 前眼部透見不良所見を伴った眼内炎に対する眼内視鏡下早期硝子体手術 (2012)
  • Author(s): 西塚弘一、武田祐介、本間慶、難波広幸、山下英俊
  • Organizer: 第66回日本臨床眼科学会総会
  • Place of Presentation: 京都国際会議場、京都
• [Presentation] Penetrating keratoplasty combined with pars plana vitrectomy assisted with 23-gauge ophthalmic endoscope (2012)
  • Author(s): Nishitsuka K, Yamashita H
  • Organizer: 25TH INTERNATIONAL CONGRESSOF GERMAN OPHTHALMICSURGEONS
  • Place of Presentation: MESSE, ニュルンベルグ(ドイツ)
• [Presentation] Roles of macrophages and dendritic cells in pathogenesis of vitreoretinal diseases 85st (2012)
  • Author(s): Nishitsuka K, Narumi M, Suzuki T,Yamakawa M, Yamashita H
  • Organizer: The Association for Research in Vision and Ophthalmology Annual meeting
  • Place of Presentation: Convention center, Fort Lauderdale(アメリカ)
• [Presentation] combined penetrating keratoplasty and pars plana vitrectomy assisted with 23-guage ophthalmic endoscope: a case report (2012)
  • Author(s): Nishitsuka K, Yamashita H
  • Organizer: The 27th APAO Congress-Joint Meeting of APAO/SOE
  • Place of Presentation: BEXCO, Busan(韓国)
• [Presentation] 網膜硝子体疾患病態におけるマクロファージ/ 樹状細胞の役割 (2012)
  • Author(s): 西塚弘一、成味真理、鈴木俊紀、山川光徳、山下英俊
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 国際フォーラム東京
• [Presentation] ブタ硝子体細胞におけるIL-1 刺激によるヒアルロン酸産生制御の検討 (2012)
  • Author(s): 柏木佳子、西塚弘一、山下英俊
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 国際フォーラム、東京
• [Presentation] Segmental Scleral Buckling For Rhegmatogenous Retinal Detachment After Cataract Surgery With Multifocal IOL Implantation: A Case Repor (2012)
  • Author(s): Nishitsuka K, Yamashita H
  • Organizer: The 3rd World Congress on Controversies in Ophthalmology
  • Place of Presentation: Swisotel The Bosphorus , Istanbul(トルコ)
• [Presentation] combined penetrating keratoplasty and pars plana vitrectomy assisted with 23-guage ophthalmic endoscope: a case report (2012)
  • Author(s): Koichi Nishitsuka
  • Organizer: The 27th APAO Congress-Joint Meeting of APAO/SOE
  • Place of Presentation: BEXCO (Busan, Korea)
• [Presentation] Roles of macrophages and dendritic cells in pathogenesis of vitreoretinal diseases (2012)
  • Author(s): Koichi Nishitsuka
  • Organizer: 85st The Association for Research in Vision and Ophthalmology Annual meeting
  • Place of Presentation: Greater Fort Lauderdale/Broward County Convention Center (Fort Lauderdale, USA)
• [Presentation] Penetrating keratoplasty combined with pars plana vitrectomy assisted with 23-gauge ophthalmic endoscope. (2012)
  • Author(s): Koichi Nishitsuka
  • Organizer: 25TH INTERNATIONAL CONGRESS OF GERMAN OPHTHALMIC SURGEONS
  • Place of Presentation: Messezentrum (Nurnberg, Germany)
• [Presentation] Efficacy of ophthalmic endoscope for vitrectomy in cases with corneal opacity (2012)
  • Author(s): Koichi Nishitsuka
  • Organizer: 108th Annual Meeting of The Korean Ophthalmological Society
  • Place of Presentation: KINTEX (Seoul, Korea)
• [Presentation] Minimally invasive scleral fixation of the intraocular lens using suture thread inserter combined with 25-Gauge vitrectomy. (2012)
  • Author(s): Koichi Nishitsuka
  • Organizer: The 8th International Symposium of Ophthalmology
  • Place of Presentation: Hong Kong Convention & Exibition Center (Hong Kong, China)
• [Presentation] Segmental Scleral Buckling For Rhegmatogenous Retinal Detachment After Cataract Surgery With Multifocal IOL Implantation: A Case Report (2012)
  • Author(s): Nishitsuka K, Yamashita H
  • Organizer: The 3rd World Congress on Controversies in Ophthalmology
  • Place of Presentation: Istanbul, Turkey
• [Presentation] 部分的強膜内陥術で治療した多焦点眼内レンズ挿入眼に合併した裂孔原性網膜剥離の1例 (2011)
  • Author(s): 西塚弘一、山下英俊
  • Organizer: TEAM2011
  • Place of Presentation: 国際フォーラム、東京
  • Year and Date: 2011-11-20
• [Presentation] Surgical therapy for submacular hemorrhage associated with ruputure of retinal arterial macroaneurysm : a case report (2011)
  • Author(s): Nishitsuka K, Yamamoto T, Yamashita H
  • Organizer: 24TH INTERNATIONALCONGRESS OF GERMANOPHTHALMIC SURGEONS
  • Place of Presentation: MESSE, ニュルンベルグ(ドイツ)
  • Year and Date: 2011-05-20
• [Presentation] ヒト・ブタ硝子体由来細胞におけるTNF-αによるヒアルロナン産生調節と細胞増殖制御 (2011)
  • Author(s): 西塚弘一,柏木佳子,山下英俊
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Effect Of Tumor Necrosis Factor-alpha On Hyaluronan Production And Cell Proliferation By Porcine And Human Vitreous Derived Cell Line (2011)
  • Author(s): Nishitsuka K, Kashiwagi Y, Yamashita H
  • Organizer: 84st The Association for Research in Vision and Ophthalmology Annual meeting
  • Place of Presentation: convention center, Fort Lauderdale,(アメリカ)
• [Presentation] Effect Of Tumor Necrosis Factor-alpha On Hyaluronan Production And Cell Proliferation By Porcine And Human Vitreous Derived Cell Line. (2011)
  • Author(s): Koichi Nishitsuka, Yoshiko Kashiwagi, Hidetoshi Yamashita
  • Organizer: 84st The Association for Research in Vision and Ophthalmology Annual meeting
  • Place of Presentation: Fort Lauderdale, USA
• [Presentation] Surgical therapy for submacular hemorrhage associated with ruputure of retinal arterial macroaneurysm : a case report. (2011)
  • Author(s): Nishitsuka K, Yamamoto T, Yamashita H
  • Organizer: 24TH INTERNATIONAL CONGRESS OF GERMAN OPHTHALMIC SURGEONS
  • Place of Presentation: Nurnberg, Germany
• [Presentation] ヒト・ブタ硝子体由来細胞におけるTNF-αによるヒアルロナン産生調節と細胞増殖制御． (2011)
  • Author(s): 西塚弘一，柏木 佳子,山下英俊
  • Organizer: 第１１５回日本眼科学会総会
  • Place of Presentation: 東京,国際フォーラム
• [Presentation] 部分的強膜内陥術で治療した多焦点眼内レンズ挿入眼に合併した裂孔原性網膜剥離の１例.
  • Author(s): 西塚 弘一、山下 英俊
  • Organizer: TEAM2011
  • Place of Presentation: 東京、国際フォーラム
• [Remarks] 山形大学研究者情報URL
  • URL: http://yudb.kj.yamagata-u.ac.jp/OUTSIDE?ISTActId=SCHKOB0010RIni001&userId=100000187&lang_kbn=0